Lamprecht M, Bogner S, Schippinger G, Steinbauer K, Fankhauser F, Hallstroem S, Schuetz B, Greilberger JF. Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; a randomized, double-blinded, placebo-controlled trial. J Int Soc Sports Nutr. 2012 Sep 20;9(1):45. doi: 10.1186/1550-2783-9-45. In this randomized, double-blind, and placebo-controlled study, 48 perimenopausal and postmenopausal women received multispecies probiotic Sanprobi Barrier in a dose of 2.5 × 109 (CFU) for five weeks. Dietary guidelines were introduced in both groups simultaneously (~1800 kcal/per day, whole grain, no-wheat meals). The study aimed to assess the variations in follicle-stimulating hormone (FSH), estradiol (E2), cortisol (as the hypothalamic-pituitary-ovarian axis hormone), and the body mass during the intervention. Postać leków to sposób, w jaki lek jest dostarczany do organizmu. Mogą to być tabletki, kapsułki, syropy, plastry, aerozole, maści itp. Wybór zależy od preferencji i potrzeb pacjenta. Postać leku wpływa na jego działanie, wchłanianie, metabolizm i wydalanie.

kapsułka zawiera 1×10 10 CFU/g całkowitej liczba bakterii probiotycznych Lactobacillus paracasei 8700:2, Lactobacillus plantarum HEAL 9 i Lactobacillus plantarum HEAL 19 oraz 1,5 µg witaminy D3; The optimal daily dose of metformin is thought to be 2000 mg, however patients with metformin intolerance cannot reach this target dose. The first of these (W1) included qualification for the study, completing the questionnaire and 3-day nutrition diaries. Cheng J, Ouwehand AC. Gastroesophageal Reflux Disease and Probiotics: A Systematic Review. Nutrients. 2020 Jan 2;12(1):132. doi: 10.3390/nu12010132. Oxidative stress being a disturbance in oxidative balance, has been associated with type 2 diabetes and linked to adverse health effects, including alterations within the intestinal microbiota and vascular endothelium.Physically active people should take special care about the tightness of their intestines. First of all, they are especially prone to the dysfunctions of the intestinal barrier due to the fact that each training session is a considerable stress factor, disturbing eubiosis (bacterial balance) of the intestines. Secondly, probiotic therapy allows to avoid digestive discomfort, often experienced during training. Thirdly, the tightness of the intestinal barrier influences the functioning of brain-gut axis, which is reflected in the functionality of the nervous system, which mainly decides about our effort and motor abilities. Zonulin is an endogenous protease, which concentration provides information about the condition of tight junctions between intestinal cells and has been used a a marker of intestinal permeability.

kapsułka zawiera łącznie 1×10 9 CFU/g Bifidobacterium lactis W51, Lactobacillus acidophilus W22, Lactobacillus plantarum W21, Lactococcus lactis W19, Bifidobacterium lactis W52, Lactobacillus paracasei W20, Lactobacillus salivarius W24; At the endpoint, FSH level has increased significantly concerning the baseline after the probiotic intake (31.91 vs. 42.00 mIU/ml; p < 0.009). Also, in the placebo group, a strong trend to elevate FSH was observed (22.31 vs. 41.99 mIU/ml; p = 0.055). Body mass has crucially decreased in reference to the baseline in both groups (PRO: 27.90 vs. 26.30 kg/m2, p<0.001; PBO: 25.90 to 24.60 kg/m2, p<0.001). Patient's metformin intolerance assessment will be questionnaire based (questionnaire adapted from Laura J. Mc Creight et al.).Store this product in the refrigerator, do not freeze. Heat or humidity may affect the live bacteria in this product, making it less effective. Participants were informed that the cardiorespiratory fitness test should take place for a minimum of 2 weeks after intense physical effort (marathon, ultramarathon). de Roos NM, Giezenaar CG, Rovers JM, Witteman BJ, Smits MG, van Hemert S. The effects of the multispecies probiotic mixture Ecologic(R)Barrier on migraine: results of an open-label pilot study. Benef Microbes. 2015;6(5):641-6. doi: 10.3920/BM2015.0003. Epub 2015 Apr 22. This incredibly advanced functional system created by the mucous membrane of enterocytes and microorganisms that live there is unfortunately extremely susceptible to damages. The largest devastation in the natural bacterial microflora is made by antibiotics, still very willingly prescribed by doctors. Importantly, they cause changes in the bacterial composition of the digestive system not only during their application, but they also have influence on the probiotic barrier for many years after antibiotic therapy. During this meeting, in accordance with the simple draw product A (group G1) was given to every second person, and product B (group G2) for the remaining persons.

To determine the level of cardiopulmonary efficiency using the Bruce protocol test on a medical treadmill were performed.

Patients who will be randomized to probiotic/ placebo "B" at visit 2 will be switched to probiotic/ placebo "A" at visit 6 and patients who will be randomized to group probiotic/ placebo "A" at visit 2 will be switched to probiotic/ placebo "B" at visit 6.

Kim J, Yun JM, Kim MK, Kwon O, Cho B. Lactobacillus gasseri BNR17 Supplementation Reduces the Visceral Fat Accumulation and Waist Circumference in Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Med Food. 2018 May;21(5):454-461. doi: 10.1089/jmf.2017.3937. Epub 2018 Apr 24. World Health Organization Obesity, and Overweight. [(accessed on 26 January 2016)]; Available online: http://www.who.int/mediacentre/factsheets/fs311/en/Probiotics have already been shown to modify the intestinal microbiota and their usage may exert a beneficial effect on the oxidative stress parameters. This is why the investigators hypothesize that it may also reduce the intensity of adverse effects associated with metformin use. Bifidobacterium lactis W52, Lactobacillus brevis W63, Lactobacillus casei W56, Lactococcus lactis W19, Lactococcus lactis W58, Lactobacillus acidophilus W37, Bifidobacterium bifidum W23, Lactobacillus salivarius W24.