Some people notice hard lumps that can form if you inject in the same place too often. This might be lipohypertrophy (also known as lipos), or could be something called cutaneous amyloidosis. These lumps can stop the insulin from working properly, so make sure you rotate where you inject and choose a different spot each time. If you notice any lumps, especially if they're not going away, speak to your healthcare professional for more advice. Ignaut DA, Opincar M, Lenox S. FlexPen and KwikPen prefilled insulin devices: a laboratory evaluation of ergonomic and injection force characteristics. J Diabetes Sci Technol. 2008;2:533–7. DiaTribeLearn. ADA 2019: day 2 highlights. Diatribe Learn. https://diatribe.org/ada-2019-day-2-highlights (2019). Accessed 2 Mar 2020. Home P, Riddle M, Cefalu WT, et al. Insulin therapy in people with type 2 diabetes: opportunities and challenges? Diabetes Care. 2014;37:1499–1508. https://care.diabetesjournals.org/content/37/6/1499.abstract.

Bux Rodeman K, Hatipoglu B. Beta-cell therapies for type 1 diabetes: transplants and bionics. Cleve Clin J Med. 2018;85:931–937. https://www.ncbi.nlm.nih.gov/pubmed/30526754.

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Pohlmeier H, Berard L, Brulle-Wohlhueter C, et al. Ease of use of the insulin glargine 300 U/mL pen injector in insulin-naïve people with type 2 diabetes. J Diabetes Sci Technol. 2017;11:263–269. https://pubmed.ncbi.nlm.nih.gov/27664062. Clinical trial ( {"type":"clinical-trial","attrs":{"text":"NCT01871961","term_id":"NCT01871961"}}NCT01871961) to assess the performance of an MTX autoinjector together with the subject perceptions about it in RA patients. Abilities of patients for using injectables. Patients with RA and to lesser extent children with JIA may be limited in their ability to self-administer conventional injectables due to the involvement of hand joints. The easier and faster procedure of using self-injectable devices would favor the administration of SC methotrexate in this group of patients. Custom Phlebotomist Keychain | Blood Tube Keychain | Phleb Keychain | Personalized Nurse Gift | Medical Staff Gift | Unique Nurse GiftFor some patients, RA therapies need to be injected. However, they may have difficulties in manipulating syringes as a result of the functional impairment of the disease and the hand small joint involvement impairing dexterity. Brown SA, Kovatchev BP, Raghinaru D, et al. Six-month randomized, multicenter trial of closed-loop control in type 1 diabetes. N Engl J Med. 2019;381:1707–17. https://doi.org/10.1056/NEJMoa1907863. This article is based on previously conducted studies and does not contain any studies with human participants or animals performed by any of the authors. Data Availability

Future refinements in this field include “smart pens” with in-built calculators to provide proper guidance to patients regarding the insulin dosage, memory functions to display the amount and time of injection, as well as automatic transmission through Bluetooth to produce computer-generated reports [ 16]. Connected Pens Story of discovery—artificial pancreas for managing type 1 diabetes: cutting-edge technology 50 years in the making. Natl Inst Diabetes Dig Kidney Dis. 2017. https://www.niddk.nih.gov/news/archive/2017/story-discovery-artificial-pancreas-managing-type1-diabetes. Freed S. New smart pens hoped to change the way we treat diabetes. Diabetes Control. https://www.diabetesincontrol.com/new-smart-pens-hoped-to-change-the-way-we-treat-diabetes/ (2020). Accessed 2 Mar 2020. Hyllested-Winge J, Sparre T, Pedersen LK. NovoPen Echo(®) insulin delivery device. Med Devices. 2016;9:11–18. https://www.ncbi.nlm.nih.gov/pubmed/26793007. Personalized BOLT ACTION PEN Custom Engraved Pens Groomsmen Gifts for Boyfriend Gift for Him Dad Men Corporate Gifts Boss Teacher GraduationFDA. FDA authorizes first interoperable insulin pump intended to allow patients to customize treatment through their individual diabetes management devices. FDA. https://www.fda.gov/news-events/press-announcements/fda-authorizes-first-interoperable-insulin-pump-intended-allow-patients-customize-treatment-through (2019). Accessed 20 Jan 2020.