Download Anti-obesity drug discovery and development Volume 1 by Atta-ur- Rahman; M Iqbal Choudhary PDF

By Atta-ur- Rahman; M Iqbal Choudhary

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3. Orlistart (Xenical® and Alli®). Sibutramine Sibutramine is a serotonin and norepinephrine reuptake inhibitor used for promoting weight loss in patients who have failed with lifestyle changes. In January 2010 it was suspended from the European market by the European Medicine Agency (EMEA), due to growing concerns about its potential negative effects on cardiovascular risk, according to the SCOUT study (Sibutramine Cardiovascular Outcome Trial) [280], a review of clinical trials including almost 10,000 overweight or obese patients at high risk of cardiovascular disease.

In addition, consumption of local glucose at muscular tissue is increased and consumption of postprandial glucose is decreased. In this MI state, FFAs are stored in muscle and liver as triglycerides. Thus, although they do not directly interfere with carbohydrate metabolism, they can lead to IR by interfering with the insulin signaling cascade [173]. The Metabolic Flexibility is considered the ability to switch from fat to carbohydrate oxidation, what appears to be usually impaired in insulin-resistant subjects; however, this Metabolic Inflexibility is mostly the consequence of impaired cellular glucose uptake [174].

The Emerging Role of Endothelium in Adiposopathy Once IR and Endothelial Dysfunction (ED) stata are settled, their pathological courses follow parallel ways, running towards type 2 diabetes mellitus and An Approach to Obesity as a Cardiometabolic Anti-Obesity Drug Discovery and Development, Vol. 2 37 atherosclerosis respectively. Nevertheless, a remarkable author in the field of inflammation and obesity, John Yudkin (Washington Hospital, London) proposed an attractive theory in 1997, considering ED as a previous step to IR and atherosclerosis in a joint way.

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