By Thierry Passeron, Jean-Paul Ortonne
The epidermis is coloured by means of a mix of pigments, which shape a part of a fancy and hugely regulated strategy. Pigmentary defects usually current with dyschromia and will be as a result of genetic defects, systemic affliction, inflammatory approaches, metabolic defects, infections, tumors, or poisonous or iatrogenic motives. This atlas is an intensive textual content written by way of key opinion leaders inside of dermatology, it has a entire structure that courses the reader in the course of the epidemiology, pathophysiology, prognosis, therapy, and differential prognosis of either universal and infrequent pigmentary issues. It illustrates the prognosis and popularity of pigmentary problems with a variety of images.
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Extra info for Atlas of Pigmentary Disorders
Macular arteritis: multiple erythematous and brown macules of the lower limbs. SYNONYMS Lymphocytic thrombophilic arteritis, macular lymphocytic arteritis. EPIDEMIOLOGY Only few cases have been reported so far. Men and women are affected but seems to be more frequent in women. Cases from 6 to 73 years of age and in all ethnicities have been reported. PATHOPHYSIOLOGY Unknown. Localization: lower limbs are constantly affected. Upper limbs are involved in less than half of the cases. EXTRACUTANEOUS SIGNS TREATMENT No systemic symptoms have been reported so far.
Mild capillary proliferation and telangiectasia in the affected areas as compared to unaffected perilesional skin. Slight perivascular inflammatory cell infiltration in the dermis. No spontaneous improvement with time. Intense pulse light or laser targeting both the vascular and the pigmentary components can be proposed. DIFFERENTIAL DIAGNOSIS • Park JH, Lee DJ, Lee YJ, Jang YH, Kang HY, Kim YC. Acquired Bilateral Telangiectatic Macules: A Distinct Clinical Entity. JAMA Dermatol. 2014;150:974-7.
Localization: penis, scrotum, vulva, vagina. • Laugier disease and other genital lentiginosis. • Genital nevus. • Melanoma. KEY REFERENCES • Barnhill RL, Albert LS, Shama SK et al. Genital lentiginosis: a clinical and histopathologic study. J Am Acad Dermatol 1990; 22:453-60. • Breathnach AS, Balus L, Amantea A. Penile lentiginosis. An ultrastructural study. Pigment Cell Res 1992; 5:404-13. EXTRACUTANEOUS SIGNS None. 45 GENITAL MELANOSIS ASSOCIATED WITH LOCALIZED DEPIGMENTATION Genital melanosis of the penis with white depigmented macules.