By Riemer H.J.A. Slart, René A. Tio, Philip H. Elsinga, Markus Schwaiger
This publication explains intimately the aptitude price of the hybrid modalities, SPECT-CT and PET-CT, within the imaging of cardiac innervation in a variety of stipulations and illnesses, together with ischemic center ailment, diabetes mellitus, center failure, amyloidosis, middle transplantation, and ventricular arrhythmias. Imaging of the brain-heart axis in neurodegenerative affliction and tension and of cardiotoxicity is additionally mentioned. the jobs of a number of the on hand tracers are absolutely thought of, and person chapters deal with radiopharmaceutical improvement less than GMP, imaging physics, and kinetic modeling software program. hugely correct historical past info is integrated at the autonomic frightened process of the center and its pathophysiology, and likewise destiny views are mentioned.
Awareness of the significance of autonomic innervation of the center for the optimum administration of cardiac sufferers is starting to be, and there's an obvious want for target size suggestions or imaging modalities. during this context, Autonomic Innervation of the guts will be of broad curiosity to clinicians, researchers, and industry.
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Extra resources for Autonomic Innervation of the Heart: Role of Molecular Imaging
Therefore, an interaction between areas of denervation, regional nerve sprouting (neural remodeling) in the left ventricle, and electrical remodeling due to heart failure all combine to create a high yield substrate for ventricular tachycardia, fibrillation, and sudden cardiac death (Hamdan et al. 2002; Adamson et al. 2003; Zhang et al. 2009; Schwartz et al. 2008; De Ferrari et al. 2011; Hauptman et al. 2012; Krum et al. 2009; Esler et al. 2010; Schlaich et al. 2009). 6 Effect of Sympathetic Stimulation on Action Potential Duration Restitution Substantial evidence links enhanced sympathetic activation with ventricular arrhythmias and sudden cardiac death.
1999; Wichter et al. 2002; Walsh and Kass 1991; Terrenoire et al. 2005; Zhang et al. 1992; Duan 2009; Vyas et al. 2006). Rabbits fed with a high-cholesterol diet for 8 weeks had significantly higher densities of growthassociated protein 43 (a protein associated with axonal growth cone) and tyrosine hydroxylase, indicating nerve sprouting and sympathetic hyperinnervation. They also showed longer QTc intervals, more QTc dispersion, longer action potential duration, increased heterogeneity of repolarisation, and higher peak calcium current density.
Arrhythmias. These studies were further confirmed by Adamson et al. who also showed that low-risk dogs recovered HRV after MI, whereas high-risk dogs continued to have depressed HRV parameters. Similar results were obtained in humans. Twenty-four-hour Holter recordings in post-MI patients showed that depressed HRV was a significant predictor of mortality after adjusting for clinical and demographic features, including ejection fraction (EF) (Farrell et al. 1991). These studies were further confirmed by other in post-MI patients, showing that impaired HRV was an independent predictor of cardiac mortality only within 6 months of MI and seemed to improve over time.