By Matt Kalaycio
The Cleveland health facility starting place, OH. textual content covers information regarding new biologic treatments and gives the health professional with sensible information for treating sufferers with leukemia. Discusses such remedies as arsenic trioxide, P-glycoprotein inhibitors, and interleukins. additionally covers genetic code adjustments. DNLM: Leukemia, treatment.
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Extra info for Biologic Therapy of Leukemia
Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graftversus-tumor effects. Blood 2001;97:3390–3400. 63. Childs R, Chernoff A, Contentin N, et al. Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. N Engl J Med 2000;343:750–758. 64. Childs R, Clave E, Contentin N, et al. Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: full donor T-cell chimerism precedes alloimmune responses.
Seventy-eight patients received fludarabine and melphalan as a preparative regimen, and eight received cladribine and melphalan. The median patient age was 52 yr (22–70 yr range). Most patients had advanced hematologic malignancies. The median percentage of donor cells at 1 mo in 75 patients was 100%. 29, respectively. Disease-free survival at 1 yr was 57% for patients in first remission and 49% for patients with more advanced disease. The conclusion was that disease control can be achieved by nonmyeloablative alloBMT.
Maraninchi D, Blaise D, Rio B, et al. Impact of T-cell depletion on outcome of allogeneic bone-marrow transplantation for standard-risk leukaemias. Lancet 1987;2:175–178. 19. Mitsuyasu R, Champlin R, Gale R, et al. Treatment of donor bone marrow with monoclonal anti-T-cell antibody and complement for the prevention of graft-versus-host disease. Ann Int Med 1986;105:20–26. 20. Goldman J, Gale R, Horowitz M, et al. Bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Ann Int Med 1988;108:806–814.