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B) The collapse of complex under excess amount of spacer-O-linked divalent glycosides. Molecular Design of Multivalent Glycosides Bearing GlcNAc, (GlcNAc)2 and LacNAc - Analysis of Cross-linking Activities with WGA and ECA Lectins 21 3. , 2009]. The enzyme catalyzes the direct transfer of GlcNAc residue to a primary diol acceptor. The divalent glycoside was shown to bind, cross-link and precipitate WGA. , 2008(b)]. , 2005). The resulting N-β-mono- and diglycosylamines were then condensed with one of the three dicarboxylic acids (n = 3, 4 or 5) with HBTU and diisopropyl ethanolamine (DIEA) in DMSO.

Toone, E. J. (2002). The cluster glycoside effect. Chem. 102, pp. 555-578. ; Rohmer, K. & Wittmann, V. (2007). Probing multivalent carbohydrate-lectin interactions by an enzyme-linked lectin assay employing covalently immobilized carbohydrates. Bioorg. Med. 15, pp. 7661-7676. -K. & Whitesides, G. M. (1998). Polyvalent interactions in biological system: Implications for design and use of multivalent ligands and inhibitors. Angew. Chem. Int. 37, pp. 2754-2794. ; Dahmann, G. & Whitesides, G. M. (1995).

6, pp. 843-849. Houseman, B. T. & Mrksich, M. (2002). Model systems for studying polyvalent carbohydrate binding interactions. Top. Curr. 218, pp. 1-44. Kabat, E. A. (1976). : Rinehart, H. New York. ; Hiratake, J. & Sakata, K. (2005). α-Glucopyranoimidazolines as intermediate analogue inhibitors of family 20 β-N-acetylglucosaminidases. Bioorg. Med. 13, pp. 1563-1571. Kiessling, L. L. & Pohl, N. L. (1996). Strength in numbers: non-natural polyvalent carbohydrate derivatives. Chem. 3, pp. 71-77. Kitov, P.

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