By Susanne Grässel, Attila Aszódi
In 3 Volumes this mini booklet sequence provides present wisdom and new views on cartilage as a really good but flexible tissue. This moment quantity is devoted to simple pathologies of the 2 most typical osteoarticular ailments affecting huge segments of the Western inhabitants, osteoarthritis and chondrodysplasias. This ebook addresses Professors, researchers and PhD scholars who're attracted to musculoskeletal and cartilage biology and pathobiology.
Read Online or Download Cartilage: Volume 2: Pathophysiology PDF
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Extra info for Cartilage: Volume 2: Pathophysiology
J Orthop Res: Off Publ Orthop Res Soc 30(3):475–481. 21536 Huveneers S, Danen EH (2009) Adhesion signaling – crosstalk between integrins, Src and Rho. J Cell Sci 122(Pt 8):1059–1069. 039446 Jang KW, Buckwalter JA, Martin JA (2014) Inhibition of cell-matrix adhesions prevents cartilage chondrocyte death following impact injury. J Orthop Res: Off Publ Orthop Res Soc 32(3):448– 454. 22523 Killian ML, Haut RC, Haut Donahue TL (2014) Acute cell viability and nitric oxide release in lateral menisci following closed-joint knee injury in a lapine model of post-traumatic osteoarthritis.
2005; Little et al. 2009). Our subsequent observation that induction of inflammatory response genes (including metalloproteinases) in surgically destabilised joints is highly mechanosensitive allowed us to speculate that excessive mechanical stress in vivo is sufficient to activate pathways that drive matrix degradation and initiate disease (Burleigh et al. 2012). 2 rticular Cartilage: Structure and Mechano-Sensing A Function The articular cartilage is a paucicellular type II collagen- and proteoglycan-rich tissue.
Arthritis Rheum 50(8):2539–2546. 20369 Guilak F, Alexopoulos LG, Upton ML, Youn I, Choi JB, Cao L, Setton LA, Haider MA (2006) The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage. Ann N Y Acad Sci 1068:498–512. 011 Guo D, Ding L, Homandberg GA (2009) Telopeptides of type II collagen upregulate proteinases and damage cartilage but are less effective than highly active fibronectin fragments. Inflamm Res: Off J Eur Histamine Res Soc [et al] 58(3):161–169.