By Mitchel P. Goldman, Doris Hexsel
It's expected that eighty percentage of ladies have a point of cellulite. even supposing there are not any everlasting strategies for cellulite, dermatologists realize that this is often a topic of value for lots of girls. This consultant studies present learn at the pathophysiology and remedy of cellulite, in addition to the numerous fresh advancements in clinical remedy, liposculpture, and pharmacy to wrestle the looks of cellulite within the lady determine. Подсчитано, что eighty процентов женщин имеют некоторую степень целлюлита. Хотя нет постоянного решения для целлюлита, дерматологи признать, что это важный вопрос для многих женщин. Это руководство рассматривает текущее исследование по патофизиологии и лечения целлюлита, а также многие последние события в медицинской терапии, липоскульптура, и фармации по борьбе появление целлюлита в женской фигуры.
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Additional info for Cellulite Pathophysiology and Treatment
The receptors that tie the protein molecules (signal protein) ask for a site at the extracellular matrix level, formed by the polypeptidical substance identified on the figure. Smaller molecules (signal protein), such as adrenaline, ask for a small extracellular site. ’’ The plasma membrane prevents a mixing of cellular contents with extracellular molecules and acts as the ﬁrst element of ‘‘contact’’ between the cells and the extracellular environment. 36 & BACCI The composition and the maintenance of this structure is essential for the generation and regulation of different functional signals and biochemicals, both in the normal and in the pathologic cells (19,20).
The main manifestations of clinical cellulite are: 1. ﬂaccid ‘‘mattress-like’’ skin, with multiple depressions and some elevations, caused by irregular retraction of the skin, forming a surface where protuberances and depressed areas alternate (Fig. 1) (6,16,34); 2. ‘‘orange peel’’ skin due to the tumefaction of the epidermis and dilation of follicular pores (6,16,34). The cutaneous surface alterations that characterize cellulite are predominantly depressed, when compared to cutaneous surface of the affected area (29).
1st ed. Sa˜o Paulo: Atheneu, 2003:350–359. 8. Murphy GF. Histopathology of the skin. In: Elder DE, Elenitsas R, Jaworsky C, Johnson BL Jr, eds. Lever’s Histopathology of the Skin. Philadelphia: Lippincott-Raven, 1997:5–50. 9. Hexsel D, Mazzuco R. Subcision: uma alternativa ciru´rgica para a lipodistroﬁa gino´ide (‘‘celulite’’) e outras alterac¸o˜es do relevo corporal. Ann Bras Dermatol 1997; 72(1):27–32. 10. Hexsel DM, De Oliveira NIM. Tratamento da celulite pela subcisa˜o. In: Horibe EK, ed. Este´tica Clı´nica e Ciru´rgica.