By Christoph Scholtissek, B.M. Richards, R. Vendrely, C. Vendrely, D.P. Bloch
The box of nucleic acids has grown to any such tremendeous dimension that it really is very unlikely to incorporate all courses in regards to the chemistry and organic function of nucleic acids in an editorial of the size awarded during this "Volume. hence, it will be important to choose crucial contributions and people no longer incorporated "in recognized studies. in lots of instances reference is made simply to the authors who summarized their really expert box in chapters of the 3 volumes of "The Nucleic Acids" (edB. E. CHARGAFF and J. N. DAVIDSON, Acad. Press, ny 1955 and 19(0) or to the "Nucleic Acid Outlines" (V. R. POTTER, Burgess Publishing Comp. Minneapolis), the place extra literature and extra exact discussions could be stumbled on. evidence and theories could be handled, yet now not lists of references. hence it isn't attainable to stick with in all situations the old improvement of an idea and to admowledge all courses that may be very important and inter esting from one other viewpoint. little or no is pointed out approximately tools within the box of nucleic acids.
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Additional info for Chemistry and Cytochemistry of Nucleic Acids and Nuclear Proteins
E. DARNELL, 1963: Demonstration of an unstable RNA and of a precursor to ribosomal RNA in HeLa cells. Proc. Nat. Acad. , U. S. 49, 240---248. SCHILDKRAUT, C. , J. MARMuR, J. R. FRESCO, and P. DoTY, 1961: Formation and properties of polyribonucleotide-polydeoxyribonucleotide helical complexes. J. BioI. Chem. 236, PC 2-PC 4. , 1955: Biosynthesis of nucleosides and nucleotides. 309-339. , 1955: Nucleases and enzymes attacking nucleic acid components. In: CHARGAFF and DAVIDSON, The Nucleic Acids I, Academic Press: New York, pp.
By this compound fowl plague virus can be inactivated stepwise as shown in Fig. 27. A short treatment renders the virus non-infectious, but hemagglutinin-this is the outer shell of the virus-and the other viral components are still being synthesized. Further inactivation leads to the loss of the ability to synthesize hemagglutinin. Thereafter the capacity for the synthesis of neuraminidase (the only enzyme of the viral coat), then that of the viral inner component-the s-antigen-and viral RNA is lost.
Induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type Ill. J. Exper. Med. 79, 137-158. , 1955: Chemistry of nucleosides and nucleotides. In: CHARGAFF and DAVIDSON, The Nucleic Acids I, Academic Press: New York, pp. 137-190. , and R. M. FRANKLIN, 1962: Preliminary data on a virus-specific enzyme system responsible for the synthesis of viral RNA. Biochem. Biophys. Res. Comm. 9, 388-392. BARONDES, S. , C. W. DINGMAN, and M. B. SPORN, 1962: In vitro stimulation of amino-acid incorporation into protein by liver nudear RNA.