Download Clinical Musculoskeletal Pathology by William F. Enneking PDF

By William F. Enneking

Stressing the significance of correlating the medical presentation, radiologic features and staging stories with the pathologic findings and diagnostic microscopic good points of musculoskeletal afflictions and ailments.

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3. On the other hand, where the lesion has penetrated the cortex there is a thin but distinct shell of reactive bone about it. 4. The lesion itself is purely radiolucent and the X-ray gives no hint as to its tissue type. 5. The age, location, and radiographic characteristics make the diagnosis of giant cell tumor highly probable. Page xiii Illustration F-2 A tomogram through the central portion of the lesion shown inIllustration F-1. 1. The ragged edge of destruction is seen in the metaphysis. 2.

These chains of procollagen then combine or polymerize to form collagen fibrils. This polymerization takes place through side-to-side bonding and is arranged at regular intervals with quarter overlapping as illustrated in the diagram. These polymerized chains of procollagen or collagen fibrils then entwine themselves in a twisting fashion not unlike that of a woven, braided rope to form collagen fibers. Page 4 within the various blast forms of connective tissue cells. Initially they are formed intracellularly as molecular precursors of collagen.

Radioactive isotopes of bone-seeking elements are frequently used for diagnostic and staging purposes. The isotope most commonly used is Technetium pyrophosphate. The phosphate ion is readily incorporated into all areas of active bone formation where mineralization is occurring. The Technetium isotope is thus attached to the bone, can be detected by and visualized on radiosensitive film and can be roughly quantitated by the intensity (Ill. F-6). Since the active skeleton is constantly undergoing simultaneous resorption and apposition, normal bone binds a modest amount of the isotope and there is a "normal" background of activity.

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