By Bannwarth W., Hinzen B.
"This innovative process allows natural and medicinal chemists to synthesize millions or perhaps thousands of doubtless attention-grabbing compounds in one response series. mixed with present tools of excessive throughput research, combinatorial tools have virtually thoroughly changed the normal step by step synthesis of power drugs." "Retaining its practice-oriented method, this new version has been completely up to date to mirror advancements in parallel synthesis, whereas a brand new bankruptcy on screening enhances the evaluation of combinatorial approach and artificial tools. the result's a guide adapted to the wishes of the undefined, with just about all the authors affiliated with best pharmaceutical companies."--BOOK JACKET. learn more... content material: Purification rules in high-speed solution-phase synthesis / Steffen Weinbrenner, C. Christoph Tzschucke -- Linkers for solid-phase natural synthesis (SPOS) and combinatorial techniques on stable helps / Willi Bannwarth -- Cyclative cleavage : a flexible inspiration in solid-phase natural chemistry / Josef Pernerstorfer -- C-C bond-forming reactions / Wolfgang K.-D. Brill, Gianluca Papeo -- Combinatorial synthesis of heterocycles / Eduard R. Felder, Andreas L. Marzinzik -- Polymer-supported reagents : practise and use in parallel natural synthesis / Berthold Hinzen, Michael G. Hahn -- Encoding recommendations for combinatorial libraries / Berthold Hinzen -- Automation and units for combinatorial chemistry and parallel natural synthesis / Christian Zechel -- Computer-assisted library layout / Andreas Dominik -- Assays for high-throughput screening in drug discovery / Christian M. Apfel, Thilo Enderle. summary: Combinatorial chemistry is a innovative strategy, which lets you synthesize thousands of compounds inside a couple of steps and in a really brief period of time. hundreds of thousands of goods, e.g. power medicinal drugs, may be analyzed in a single cross, so you be aware of very quickly if one or a number of elements on your product mix convey organic task. learn more...
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Additional resources for Combinatorial Chemistry, 2nd Ed.
Alternatively, the linker can be first coupled to the amine, after which the adduct is attached to the solid support.
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J. Org. Chem. 62, 5908–5919 (1997). Bioorg. Med. Chem. Lett. , Obrecht (1998). 55 Parlow J. , South M. 1 General Synthesis on solid supports involves three key elements: the solid support, the linker element, and the compound attached to the linker. The solid support should be stable to a wide range of reaction conditions and allow for reactions in different types of solvents and at elevated temperatures. The need for linkers arises from the fact that the range of suitable functionalities available on resins is severely restricted, and so consequently is the range of functional groups that can be directly attached to the solid support.