By Herschel S. Zackheim
Cutaneous T-cell lymphoma (CTCL) is a common time period for lots of lymphomas of the outside together with mycosis Fungoides and Sezary syndrome. This e-book provides the state-of-the-art in CTCL epidemiology, scientific positive factors, pathology, immunochemistry, diagnostic molecular thoughts, staging and diagnosis, and remedy. Edited by way of one of many top specialists within the illness, Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sezary Syndrome offers accomplished insurance of the affliction and provides options for analysis and cutting-edge therapy modalities, equivalent to ultraviolet gentle, steroids, and topical chemotherapeutics
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Additional info for Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sezary Syndrome
J. Dermatol. 144, 1010, 2001. 20. Olsen, E. et al. Pivotal phase III trial of two dose levels of denileukin diftitox for the treatment of cutaneous T-cell lymphoma. J. Clin. Oncol. 19, 376, 2001. 21. Duvic, M. et al. Bexarotene is effective and safe for treatment of refractory advancedstage cutaneous T-cell lymphoma: multinational phase II–III trial results. J. Clin. Oncol. 19, 2456, 2001. 22. Talpur, R. et al. Optimizing bexarotene therapy for cutaneous T-cell lymphoma. J. Am. Acad. Dermatol. 47, 672, 2002.
A focally dense interstitial infiltrate of lymphocytes is present in the reticular dermis. The epidermis is predominantly spared. (b) A higher power view highlighting increased mucin within the follicle (H&E, 20×). The adjacent perifollicular infiltrate contains atypical lymphocytes with admixed occasional histiocytes and eosinophils. 8 (a) Granulomatous mycosis fungoides (MF; H&E, 2×) demonstrates palisading histiocytes with admixed atypical lymphocytes extending from the reticular dermis into the deep dermis and subcutis.
Dermatol. 40, 418, 1999. 5. H. et al. Long-term outcome of 525 patients with mycosis fungoides and Sezary syndrome. Arch. Dermatol. 139, 857, 2003. 6. J. et al. Cutaneous histopathology of Sezary syndrome: a study of 41 cases with a proven circulating T-cell clone. J. Cutan. Pathol. 24, 286, 1997. 7. , and Buechner, S. The treatment of Sezary syndrome. J. Am. Acad. Dermatol. 10, 1000, 1984. Sezary Syndrome 47 8. A. and von den Driesch, P. Treatment of erythrodermic cutaneous T-cell lymphoma with intermittent chlorambucil and fluocortolone therapy.