By Guillaume Bussone
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1993;120(1): 100–6. Rijlaarsdam JU, Willemze R. Cutaneous pseudolymphomas: classification and differential diagnosis. Semin Dermatol. 1994;13(3):187–96. Singh ZN, Tretiakova MS, Shea CR, Petronic-Rosic VM. Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo. Mod Pathol. 2006;19(9):1255–60. 24 Swerdlow SJ, Campo E, Harris NL, Jaffe ES, Pileri S, Stein H, Thiele J, Vardiman JW, editors. WHO classification of tumors of haematopoieitic and lymphoid tissues, WHO press, Geneva, Switzerland; 4th ed.
In transformed MF, at least 25 % are large cells with small cerebriform cells in the background. If the large cells are less than 25 % and the lump is solitary or few, with lymphocytes composed of atypical small- and medium-sized population that are monoclonal by T-cell gene rearrangement, then a primary cutaneous smalland medium-sized T-cell lymphoma is a prime consideration (see Chap. 10 for discussion of these entities). Subcutaneous Pattern Subcutaneous pattern is seen in both reactive and neoplastic processes.
Prominent endothelial venules with plump pink cytoplasm, sometimes arborizing, surrounded by perivascular atypical small- and medium-sized pleomorphic lymphocytes that coexpress T cell and follicle center cell-associated markers, such as CD10, Bcl-6, and PD-1, suggest a cutaneous involvement by angioimmunoblastic T-cell lymphoma, a systemic disease with frequent skin involvement (Martel et al. 2000; Patsouris et al. 1989). Medium-sized vessels are prominently involved in (angiocentric) NK/T-cell lymphomas, nasal type of extranodal or extranasal lymphomas.