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By Bruce R. Smoller

Dermatopathology: The Basics will function an efficient and effective guide for the scholar of dermatopathology, and as a realistic bench reference for the practising diagnostician who wishes fast entry to standards which are invaluable in differentiating histologically related entities. The chapters include crucial bullet issues prepared in prepared outlines taking into consideration quick access and direct comparability among entities. the flowery pictorial documentation also will allow the booklet to function an atlas of the most typical dermatologic disorders.

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6 This shave biopsy of a syringoma (A) is too shallow to allow for confident distinction from the superficial portion of other basaloid lesions such as basal cell carcinoma (B) and trichoepithelioma (C) Presumed Neoplastic Processes 43 A B C D Fig. 7 A shallow shave biopsy can make a morpheaform basal cell carcinoma (A), a desmoplastic trichoepithelioma (B), and a syringoma (C) very difficult to distinguish from the aggressive look-alike microcystic adnexal carcinoma (D) – Microcystic adnexal carcinoma vs.

4 This shave biopsy of a basal cell carcinoma does not provide adequate lesional tissue to confidently diagnose the tumor type • Pathologists tend to err on the side of malignancy when presented with small samplings of neoplastic processes • Actinic keratoses or irritated seborrheic keratoses could be misdiagnosed as squamous cell carcinoma if incompletely visualized (Fig. 5) Fig. 5 The cytologic atypia, large nuclei, and prominent nucleoli (A) in this irritated seborrheic keratosis may be mistaken for malignant atypia of a squamous cell carcinoma without the benefit of the overall morphology (B) 42 2 How to Maximize Information from a Skin Biopsy • A deep shave biopsy or a punch biopsy are the recommended specimens as a specimen that is too shallow can make it very difficult to distinguish – Basal cell carcinoma from trichoepithelioma (Fig.

4) Fig. 4 This shave biopsy of a basal cell carcinoma does not provide adequate lesional tissue to confidently diagnose the tumor type • Pathologists tend to err on the side of malignancy when presented with small samplings of neoplastic processes • Actinic keratoses or irritated seborrheic keratoses could be misdiagnosed as squamous cell carcinoma if incompletely visualized (Fig. 5) Fig. 5 The cytologic atypia, large nuclei, and prominent nucleoli (A) in this irritated seborrheic keratosis may be mistaken for malignant atypia of a squamous cell carcinoma without the benefit of the overall morphology (B) 42 2 How to Maximize Information from a Skin Biopsy • A deep shave biopsy or a punch biopsy are the recommended specimens as a specimen that is too shallow can make it very difficult to distinguish – Basal cell carcinoma from trichoepithelioma (Fig.

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