By Christiaan Schiepers, A.L. Baert
Second version - completely up-to-date and revised. presents the newest replace on systems in nuclear medication. records the position of puppy in oncology and introduces twin modality imaging with PET/CT. comprises sections on molecular imaging and destiny customers. Represents an accessory to straightforward wisdom of diagnostic nuclear drugs.
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Extra info for Diagnostic Nuclear Medicine (Medical Radiology Diagnostic Imaging)
J Nucl Med 36:1196-1200 Cagnin A, Brooks DJ, Kennedy AM, Gunn RN, Myers R, Turkheimer FE et al (2001) In-vivo measurement of activated microglia in dementia. Lancet 358:461-467 Choksey MS, Costa DC, Iannotti F, Ell PJ, Chochard HA (1989) Tc-99m-HMPAO SPECT and cerebral blood flow: a study of CO2 reactivity. Nucl Med Commun 10:609-618 Coenen HH, Laufer P, Stocklin G, Wienhard K, Pawlik G, Bocker-Schwarz HG, Heiss WD (1987) 3-N-(2’[18F]fluoroet hyl)spiperone: a new ligand for cerebral dopamine receptor studies with PET.
As for amino acid transport into tumor cells, the SPECT tracer 123I-methyl-tyrosine, has been evaluated in small patient series with promising results (Biersack et al. 1989; Langen 1997). 2 Imaging of Cerebral Tumors by Antibodies and Receptor-Bound Tracers Imaging modalities based on the use of SPECT and monoclonal antibodies is attracting increasing G. Lucignani and J. J. Frost 28 interest, in particular for those aimed at the signal amplification by tumor pretargeting techniques. This is best achieved by the administration of biotinylated monoclonal antibody, followed by the administration of the radioactive tracer (two-step technique), or by the administration of avidin, after the monoclonal antibody, and then by the tracer administration (three-step technique).
Additionally, images reflect average metabolic activity over an approximate 30-min time interval after injection. Accordingly, images reflect an admixture of interictal, ictal and postictal metabolism, which may be difficult to interpret. For example, some 18F-FDG PET studies acquired during an ictus have shown global hypometabolism. In these instances it is thought that the 18F-FDG PET image reflects predominantly postictal depres- G. Lucignani and J. J. Frost sion of metabolism when the actual seizure activity occurs during a small portion of the uptake period.