Download Directory of Therapeutic Enzymes by Barry M. McGrath, Gary Walsh PDF

By Barry M. McGrath, Gary Walsh

Conscientiously crafted to supply tightly centred and authoritative info, the Directory of healing Enzymes covers all authorized healing enzymes at present utilized in drugs. Written quite often by means of specialists, the booklet contains details sourced at once from the corporate that constructed or synthetic the product. It explores significant improvement matters, from production and advertising to supply of the completed product.

Chapter 1 reports utilized enzymology whereas bankruptcy 2 delineates idea and functions. among them, the 1st chapters set the correct backdrop for the rest chapters, which concentrate on genuine enzyme items that experience received regulatory acclaim for common scientific use. The bankruptcy authors speak about the biochemistry of the enzymes, the reactions they catalyze, how they're produced or synthetic, and their clinical functions.

The booklet highlights the various purposes of licensed healing enzymes, together with use within the therapy of blood-clotting issues, definite cancers, and quite a few genetic problems. Illustrated with tables and figures that aid the textual content, the ebook is a unmarried resource of in-depth technical information.

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Thus, rational design, the hypothesis-driven strategy to solve problems that beset many therapeutic enzymes, is widely used to enhance enzyme performance [217]. Identification of key aa residues involved, for example, in substrate binding or catalytic activity, could be altered by SDM and variants assayed for enhanced performance in a clinical setting. An elegant example of applying rational design to improve a therapeutic enzymes clinical performance has recently been described by Berg et al. [218], who have redesigned activated protein C (APC).

The PEG-modified form of L-Asp displays a significant increase in serum half-life, and reduced immunogenicity compared with unmodified forms of L-Asp [234]. 6). Recently, a PEGylated form of arginine deiminase (ADI), an arginine-degrading enzyme, has been shown to be effective in inhibiting human melanomas and hepatocellular carcinomas, which are auxotrophic for arginine due to lack of arginosuccinate synthethase activity. The PEGylated ADI (PEG-ADI), despite showing a reduced activity, had an increased serum half-life and displayed reduced immunogenicity, relative to wild-type, unmodified ADI [235,236].

Abbreviations: D-MTEH ϭ D-5-(2-methyltioethyl) hydantoin; ee ϭ enantiomeric excess; E ϭ enantiomeric selectivity factor; GSSM ϭ gene site saturation mutagenesis; MS ϭ mass spectrometry; SIMPLEX ϭ single-molecule-PCR-linked in vitro expression; ESI-MS ϭ electrospray ionization mass spectrometry. 37 7/5/2005 9:13:32 AM Copyright © 2006 Taylor & Francis Group, LLC 38 Directory of Therapeutic Enzymes reviewed throughout this book and elsewhere [207,209–211], an increasing number of enzymes have been developed, tested in clinical trials, and marketed for use, with many more currently in development as therapeutic agents.

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