Wirngo FE, et al. (2016). The physiologicaleffects of dandelion (taraxacum officinale) in type 2 diabetes. Xia D, et al. (2013). Protective effects of theflavonoid-rich fraction from rhizomes of smilax glabra Roxb. on carbontetrachloride-induced hepatotoxicity in rats.

The stimulation of these bitter receptors promotes healthy digestion by increasing digestive secretions. This leads to better absorption of nutrients, natural detoxification of the liver, and — thanks to the gut-brain connection — bitters can even have a positive effect on stress. Artichoke leaf contains the flavonoid silymarin, a powerful liver protectant, and has been shown to help liver cells regenerate (in mice). Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Calway T, et al. (2012). Chemical andpharmacological studies of Oplopanax horridus, a North American botanical.

Herbs and flowers: mint, sage, lemongrass, peppermint, sorrel, lavender, chamomile, hibiscus, passionflower, yarrow, rose, milk thistle, and valerian Ben Salem M, et al. (2015). Pharmacologicalstudies of artichoke leaf extract and their health benefits.

After 2 weeks, strain the liquid through a cheesecloth-lined funnel into another large jar. Squeeze the cheesecloth over the jar and transfer solids to a small saucepan. Cover the jar and set aside. Rinse out original Mason jar.Prepare low ball glass with a large ice cube. Add the whiskey, bitters, and sugar to a mixing glass filled with ice and stir for 20-30 seconds. Start with quality ingredients: Use a high-quality rye whiskey or bourbon as the base for your Old Fashioned. Look for a whiskey with rich flavors and a smooth finish. Yamaguchi K, et al. (2006). Anti-proliferativeeffect of horehound leaf and wild cherry bark extracts on human colorectalcancer cells.

When you take it might matter though: If your goal of using bitters is to ease digestive issues, consumption should occur either directly before or after meals. Aromatics can add flavor, fragrance, sweetness, and balance to bitters. Some aromatics even come with potent health benefits, such as turmeric, citrus, and lavender. Park CM, et al. (2014). TOP 1 and 2,polysaccharides from Taraxacum officinale, inhibit NFκB-mediated inflammationand accelerate Nrf2-induced antioxidative potential through the modulation ofPI3K-Akt signaling pathway in RAW 264.7 cells.Spices: cinnamon, cassia, turmeric, cloves, cardamom, chiles, fennel, ginger, nutmeg, juniper berries, star anise, vanilla beans, and peppercorns Devil’s club root is used as a treatment for respiratory, cardiovascular, and gastrointestinal issues. After 1 week, strain the jar with the liquid and the solids through a cheesecloth-lined funnel set over the jar containing the bourbon. Add the maple syrup to the jar and stir to combine, then cover and shake well. Zhang WL, et al. (2013). Chemical and biologicalassessment of Angelica roots from different cultivated regions in a Chineseherbal decoction danggui buxue tang. If you have an idea of what you want to put together, you can follow these instructions. Directions: