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Aureus and S. pyogenes at the retapamulin in vitro MIC for these organisms. At concentrations 1000× the in vitro MIC, retapamulin is bactericidal against these same organisms. Retapamulin demonstrates no in vitro target-specific cross-resistance with other classes of antibiotics. Two mechanisms that cause reduced susceptibility to retapamulin identified in vitro are mutations in ribosomal protein L3 or the presence of an efflux mechanism. Decreased susceptibility of S. 53 Pharmacokinetics. Systemic exposure following topical application of retapamulin through intact and abraded skin was low.

Nichols RL, Graham DR, Barriere SL, et al. Treatment of hospitalized patients with complicated gram-positive skin and skin structure infections: two randomized, multicentre studies of quinupristin/dalfopristin versus cefazolin, oxacillin or vancomycin. Synercid Skin and Skin Structure Infection Group. J Antimicrob Chemother. 1999;44:263–73. 24. Fagon J, Patrick H, Haas DW, et al. Treatment of grampositive nosocomial pneumonia. Prospective randomized comparison of quinupristin/dalfopristin versus vancomycin.

Murthy S, Hawksworth NR, Cree I. 02%). Cornea. 2002;21:237–9. 28. Tanner J, Swarbrook S, Stuart J. Surgical hand antisepsis to reduce surgical site infection. Cochrane Database Syst Rev. 2008; CD004288. 29. Gould D, Ream E. Assessing nurses’ hand decontamination performance. Nurs Times. 1993;89:47–50. 30. Gould DJ, Chudleigh J, Drey NS, Moralejo D. Measuring handwashing performance in health service audits and research studies. J Hosp Infect. 2007;66:109–15. 31. Taylor LJ. An evaluation of handwashing techniques-1.

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