By Rebecca A. Bader
Polymers have performed a serious position within the rational layout and alertness of drug supply structures that raise the efficacy and decrease the toxicity of latest and standard therapeutics. starting with an advent to the basics of drug supply, Engineering Polymer platforms for more suitable Drug Delivery explores conventional drug supply innovations in addition to rising complex drug supply strategies. via reviewing many varieties of polymeric drug supply platforms, and together with key issues, labored examples and homework difficulties, this booklet will function a consultant to for experts and non-specialists in addition to a graduate point textual content for drug supply courses.
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Additional resources for Engineering Polymer Systems for Improved Drug Delivery
METABOLIC AND CHEMICAL CONCERNS 39 lining the brain capillaries contain tight junctions, creating a less permeable barrier between the blood and the CNS . Non-brain capillaries contain endothelial cells as well, but the spaces between them generally contain more, and larger, openings than brain capillaries. As a result, molecules less than 500 Da can passively diffuse through the openings and reach the tissues. In contrast, the tight-junction-regulated brain capillaries do not allow diffusion between cells, leaving only membrane diffusion as a means of transport into the brain .
2 Ligand-Receptor Binding Although some drugs act through chemical reactions or physical associations with molecules within the body, a number of other drugs are used to elicit, change, or prevent a cellular response via ligand-receptor binding interactions. 5. Typical dose–response curves looks at both efﬁcacy and toxicity. The therapeutic window is the dosing range that can be used to safely treat a disease. , a cytokine or hormone), that is, the drug acts as an antagonist, or (ii) elicits a physiological response equal to or greater than what would result from the binding of an endogenous ligand, that is, the drug acts as an agonist.
P 247. 35. Welty JR. Fundamentals of Momentum, Heat, and Mass Transfer. 4th ed. New York: Wiley xii; 2001. p 759. 36. Cussler EL. Diffusion: Mass Transfer in Fluid Systems. 2nd ed. New York: Cambridge University Press xviii; 1997. p 580. 37. Bird RB, Stewart WE, Lightfoot EN. Transport Phenomena. 2nd, Wiley international ed. New York: John Wiley & Sons, Inc. xii; 2002. p 895. 38. Crank J. The Mathematics of Diffusion. 2d ed. Oxford, England: Clarendon Press viii; 1975. p 414. 39. Bader RA, Kao WJ.