Download From Secretion to Glaucom by Mortimer M. Civan, Arnost Kleineller, Douglas M. Fambrough, PDF

By Mortimer M. Civan, Arnost Kleineller, Douglas M. Fambrough, Dale J. Benos

This quantity provides a easy consensus of the way the aqueous humor is shaped and exits throughout the trabecular meshwork and canal of Schlemm. It provides a well timed replace to present wisdom of the molecular delivery mechanisms which underlie aqueous humor dynamics. additionally, it offers a concise description of the medical ways used for assessing those uncomplicated shipping strategies. The ebook emphasizes the phenomenon of the diurnal rhythm of aqueous humor formation, from either the scientific and molecular issues of view. This phenomenon offers the main indication that aqueous humor secretion is regulated. Key gains * Introduces the mechanisms of aqueous humor formation and outflow * Describes the medical learn of aqueous humor dynamics * Exposes the examine methods at present utilized * Emphasizes the diurnal rhythm of aqueous humor secretion * presents expertise of unanswered questions

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Chem. 257, 10338-10343. , Freitag, A. , and Coca-Prados, M. (1990). Cellular distribution and differential gene expression of the three subunit isoforms of the Na,K-ATPase in the ocular ciliary epithelium. J. Biol. Chem. 265,2935-2940. , Martin-Alonso, J. , and Coca-Prados, M. (1991). K+-ATPasegenes reveals a gradient of isoforms along the nonpigmented ciliary epithelium: Functional implications in aqueous humor secretion. J. Cell Physiol. 149, 184-194. Glynn, I. M. (1993). Annual review prize lecture: All hands to the sodium pump.

1997b). Hypotonic swelling of bovine PE cells activates a large-conductance (-100 pS) and a lowconductance (-9 pS) C1- channel (Zhang and Jacob, 1997). , 1997a). Clearly, one or more of the C1 channels must be different in the PE and NPE cells. The mechanism of tamoxifen's differential action on the two volume-activated C1- channels is not yet known. , 1992), but at the same concentration acts as a calmodulin antagonist (Lam, 1984). It is unclear whether the different tamoxifen effects on the volume-activated C1- channels of PE and NPE cells arise from 16 Mortimer M.

Cell Physiol. 137,384-389. , Stumpff. , and Wiederholt, M. (1989). Role of HC03- in regulation of cytoplasmic pH in ciliary epithelial cells. Am. J. Physiol. 257, C696-005. Jacob, T. J. C. (1991a). Identification of a low-threshold T-type calcium channel in bovine ciliary epithelial cells. Am. J. Physiol. 261, C808-C813. Jacob, T. J. C. (1991b). Two outward K' currents in bovine pigmented ciliary epithelial cells: IK(Ca) and IK("). Am. J. Physiol. 261, C1055-ClO62. Jacob, T. J. , and Civan, M. M.

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