By Yu-Chen Hu
"Gene treatment for Cartilage and Bone Tissue Engineering" outlines the tissue engineering and attainable functions of gene remedy within the box of biomedical engineering in addition to easy rules of gene treatment, vectors and gene supply, in particular for cartilage and bone engineering. it truly is meant for tissue engineers, phone therapists, regenerative drugs scientists and engineers, gene therapist and virologists. Dr. Yu-Chen Hu is a distinctive Professor on the division of Chemical Engineering, nationwide Tsing Hua collage and has got the exceptional learn Award (National technological know-how Council), Asia examine Award (Society of Chemical Engineers, Japan) and Professor Tsai-Teh Lai Award (Taiwan Institute of Chemical Engineers). he's additionally a fellow of the yankee Institute for clinical and organic Engineering (AIMBE) and a member of the Tissue Engineering overseas & Regenerative drugs Society (TERMIS)-Asia Pacific Council.
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Additional resources for Gene Therapy for Cartilage and Bone Tissue Engineering
Chick HE, Nowrouzi A, Fronza R, McDonald RA, Kane NM, Alba R et al (2012) Integrasedeficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk. Hum Gene Ther 23:1247–1257 56. Imperiale MJ, Kochanek S (2004) Adenovirus vectors: biology, design, and production. Curr Top Microbiol Immunol 273:335–357 57. Roessler BJ, Allen ED, Wilson JM, Hartman JW, Davidson BL (1993) Adenoviral-mediated gene transfer to rabbit synovium in vivo. J Clin Invest 92:1085–1092 58.
They demonstrate that VEGF acts synergistically with BMP-4 to enhance the calvarial bone formation via the endochondral ossification pathway, by increasing the recruitment of MSCs, enhancing cell survival and augmenting cartilage formation in the early stages of endochondral bone formation . A subsequent study also shows that simultaneous expression of BMP-2 and VEGF by retrovirustransduced MDSCs stimulates calvarial bone formation . The supportive roles of VEGF on calvarial bone healing mediated by BMP-2 are further confirmed later [98, 99].
Banasik MB, McCray PB (2009) Integrase-defective lentiviral vectors: progress and applications. Gene Ther 17:150–157 55. Chick HE, Nowrouzi A, Fronza R, McDonald RA, Kane NM, Alba R et al (2012) Integrasedeficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk. Hum Gene Ther 23:1247–1257 56. Imperiale MJ, Kochanek S (2004) Adenovirus vectors: biology, design, and production. Curr Top Microbiol Immunol 273:335–357 57. Roessler BJ, Allen ED, Wilson JM, Hartman JW, Davidson BL (1993) Adenoviral-mediated gene transfer to rabbit synovium in vivo.