By R P Lanza
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The rates of extraction and elimination of the radiopharmaceutical in the organ of interest, blood and excretory organs are calculated. These data are sometimes used to estimate radiation dose. IN VITRO MODELS REGISTRA TION These are highly specific systems used for studying the mechanisms of uptake, retention, elimination and biochemical events associated with the radiopharmaceuticals. 1. The in vitra model is relatively inex. pensive and easily manipulated. Although in vitra studies can prov1de mformation on what the transport mechanism of a radiopharmaceutieal might be in viva, an in vitra model is not a substitute for animal studies because the interplay of physiologie and biochemie al events ta king place in viva cannot be adequately mimicked in an in vitra model.