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By M. R. Raju

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S. Department of Commerce, Springfield, VA 22151), U. S. Atomic Energy Commission 1 report CONF-680410, pp. 23. Kaplan, H. S. (1970) Radiobiology s contribution to radio­ therapy: Promise or mirage? Radiat. Res. 43, 460-476. Kolstad, P. (1964) Vascularization, Oxygen Tension, and Radiocurability in Cancer of the Cervix: A Colpophotographic, Polarographic, and Clinical Study (Universitetsforlaget, Oslo/London). , and Sinclair, W. K. (1968) X-ray sensitivity of synchronized Chinese hamster cells irradiated during hypoxia.

LET recognizes no delta-ray tracks and is numerically the same as the stopping power of a given charged particle in a specified medium. IOL 200 400 600 DOSE ( r o d ) Fig. 2-4. Survival curves of human kidney cells under aerated conditions for X rays and heavy ions (replotted from Todd, 1964). With increasing LET, there is a steady increase in sensi­ tivity up to 220 keV/pm, corresponding to the LET for carbon ions (Fig. 2-4). The survival curves have shoulders up to an LET of 165 keV/pm (boron ions).

The Elkind intracellular recov­ ery phenomenon is one of the major mechanisms involved in tissue recovery. It is believed that fractionated doses produce more effect on tumor tissues than on normal tissues. This may be because normal tissues can repair sublethal damage more effectively than malignant tissues, although the differences in proliferation or reoxygenation cannot be ruled out. Recent experiments by Denekamp and Stewart (1979) using Heavy Particle Radiotherapy 32 T — | — i — | — I — | — i — n — i — I — i — r J 0 1—r L 4 8 12 16 20 24 28 32 T i m e B e t w e e n T w o Doses ( h r ) Fig.

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