By Srihari S. Naidu
This e-book offers a finished medical assessment of Hypertrophic Cardiomyopathy (HCM), the commonest genetic illness of the center characterised through dysfunctional contractility on the sarcomere point, leading to the advance of irregular and infrequently focal hypertrophy on a macroscopic point.
Editor, Srihari S. Naidu, has introduced jointly an international popular workforce of specialists to check quite a few diversified subject matters yet, with a realistic concentration that might allow readers to set up the evidence-based most sensible perform in any capability situation. therapy modalities together with drugs, pacemakers and defibrillators, and invasive septal aid treatment (both surgical myectomy and alcohol septal ablation) may be mentioned. Chapters on genetics, kinfolk screening, way of life matters, and athletic screening have also been further given the continued controversies and transformations of opinion on lots of those matters.
Each bankruptcy inside of Hypertrophic Cardiomyopathy starts off with key issues of information and ends with medical pearls that experience no longer formerly been disseminated to the broader group. the sensible technique of the total e-book maintains with devoted chapters on making a middle of Excellence, together with the best way to facilitate the multi-disciplinary procedure, and on case-based stories and discussions permitting readers to extra know how to combine the data received from every one bankruptcy into the great and longitudinal care of the person sufferer and kinfolk. The final bankruptcy takes the reader throughout the administration of exact sufferers, exhibiting over many years the nuances to analysis and administration and the occasionally abrupt adjustments during their ailments that necessitate correspondingly abrupt changes in remedy.
This e-book might be a necessary textual content for Trainees, Fellows, citizens and board-certified physicians in cardiology, interventional cardiology, cardiac surgical procedure, cardiac imaging, activities drugs, paediatric cardiology, genetics and genetic counselling, and electrophysiology.
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Additional resources for Hypertrophic Cardiomyopathy: Foreword by Bernard Gersh and Historical Context by Eugene Braunwald
Prognostic significance of 24-h ambulatory electrocardiographic monitoring in patients with hypertrophic cardiomyopathy: a prospective study. Am J Cardiol. 1981;48:252–7. 74. Monserrat L, Elliott PM, Gimeno JR, Sharma S, Penas-Lado M, McKenna WJ. Non-sustained ventricular tachycardia in hypertrophic cardiomyopathy: an independent marker of sudden death risk in young patients. J Am Coll Cardiol. 2003;42:873–9. 75. Spirito P, Rapezzi C, Autore C, et al. Prognosis of asymptomatic patients with hypertrophic cardiomyopathy and non-sustained ventricular tachycardia.
Circ Cardiovasc Genet. 2012;5:10–7. 25. Page SP, Kounas S, Syrris P, et al. Cardiac myosin binding proteinC mutations in families with hypertrophic cardiomyopathy. Disease expression in relation to age, gender, and long term outcome. Circ Cardiovasc Genet. 2012;5:156–66. 26. Van Driest SL, Vasile VC, Ommen SR, et al. Myosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2004;44:1903–10. 27. Mogensen J, Murphy RT, Kubo T, et al. Frequency and clinical expression of cardiac troponin I mutations in 748 consecutive families with hypertrophic cardiomyopathy.
Li et al. association with left ventricular apical aneurysm. Br Heart J. 1989;61:178–81. 80. Gimeno JR, Tome-Esteban M, Lofiego C, et al. Exercise-induced ventricular arrhythmias and risk of sudden cardiac death in patients with hypertrophic cardiomyopathy. Eur Heart J. 2009;30: 2599–605. 3 Pathology and Pathophysiology Kazuyuki Yahagi, Elena Ladich, and Renu Virmani Abstract Hypertrophic cardiomyopathy (HCM) is a primary and usually familial cardiac disorder with heterogeneous expression, unique pathophysiology, and a diverse clinical course.