By Laurence S. Baskin M.D., FAAP (auth.), Laurence S. Baskin (eds.)
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Additional resources for Hypospadias and Genital Development
1979, Aetiological studies of hypospadias in Hungary. Hum Hered,38:4550. 42 Kolon et al. Czeizel, A, 1985, Increasing trends in congenital malformations of male external genitalia. Lancet, 1:462-463. 1. , 1984, The effect of five synthetic progestational compounds on 5 alpha reductase activity in genital skin fibroblast monolaYERS. Steroids, 43:13-17. , 1998, Rise in the prevalence of hypospadias. Lancet, 351:770. , 1998, Hypospadias. In: Walsh PC, Retik AB, Vaughan ED, Wein AJ, eds. Campbell's Urology, 7<1> ed.
2001), however, studied the enzymatic function of 3~ hydroxysteroid dehydrogenase, p450cl7 (17,20 lyase, 17a hydroxylase) and 17~ hydroxysteroid dehydrogenase of 75 patients and found that the enzymatic activity of the androgen pathway was varied and differences based on age or the severity of hypospadias did not reach statistical significance. Therefore, no abnormalities in the androgen pathway as a cause of hypospadias could be documented. They concluded that the enzymatic dysfunction of these enzymes was a rare cause of hypospadias.
106(1): p. 3-11; discussion 12. , 1996, Tubularized incised plate hypospadias repair: results of a multicenter experience, J Urol. 156(2 Pt 2): p. 839-41. , 1990, Genetic and environmental factors in hypospadias, J Med Genet. 27(9): p. 55963. Sutherland, R. , 1996, Androgen receptor gene mutations are rarely associated with isolated penile hypospadias, J Urol. 156(2 Pt 2): p. 828-31. , 1974, Study of the incidence of hypospadias in Rochester, Minnesota 1940-1970, and a case-control comparison of possible etiologic factors, Mayo C/in Proc.