By Polina Prokopovich
Half 1 basics and issues of inhaler units: Anatomy and pathophysiology of breathing procedure; heritage of inhaler units; Tribology of inhaler units and parts; Novel coatings and biotechnology developments in inhaler units; Microbial keep watch over and defense in inhalation units. half 2 Drug formulations for inhaler units: Chitosan and inhalers: A bioadhesive polymer for pulmonary drug supply; Polyelectrolyte assemblies for drug garage and supply: Multilayers, nanocapsules, and multicapsules; Functionalized core-shell nanoparticles for clinical functions.
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Extra info for Inhaler Devices Fundamentals, Design and Drug Delivery.
P. , The Friction and Lubrication of Solids, Oxford: Clarendon Press, 2001. 16. Gohar R. , Fundamentals of Tribology, London: Imperial College Press, 2008. 17. Prokopovich P. , A multi-asperity contact adhesion model for universal asperity height and radius of curvature distributions. Langmuir 2010; 26(22): 17028– 17036. 18. Prokopovich P. and Perni S. Comparison of JKR- and DMT-based multi-asperity adhesion model: theory and experiment. Colloids and Surfaces A, 2011, 383 (1–3): 95–101. 19. , Geometry and contact pressure of an O-ring mounted in a seal groove, Ind Eng Chem Res, 1990, 29, pp.
9. Prokopovich P. and Starov V. Adhesion models: from single asperity to multiasperities contact interactions. An invited review paper to Advances in Colloid and Interface Science, 2011, 168(1–2): 210–222. 10. , Rahnejat H. , Tribology of rough ultrafilm contacts in drug delivery devices. Proc IMechE Part C: J. Mechanical Engineering Science 2008, 222, pp. 2209–2216. 11. , Israelachvili J. , Frictional forces and Amonton’s law: from the molecular to the macroscopic scale, J Phys Chem B, 2004, 108, pp.
These devices are as portable and as easy to use as the pMDIs but the aerosol is produced by the inhalation of the patient, which © Woodhead Publishing Limited, 2013 26 Inhaler devices effectively reduces co-ordination issues. A further benefit of the DPI is that it does not require a propellant (Harris, 2008). From the vast number of studies performed on the particle size of inhalation aerosols, Frijlink and de Boer indicate that the optimal aerodynamic diameter for DPIs, that are operated at inspiratory peak flow rates between 30 and 150 L/min (Frijlink and de Boer, 2005), lies somewhere in the range between 1 and 5 mm.