By Gil Yosipovitch, Malcolm W. Greaves, Alan B. Fleischer Jr., Francis McGlone
Supplying information at the pharmacology of itch, recommendations of itch review, and neurogenic itch, this reference provides new suggestions within the neurophysiology and relevant mechanisms of itch, animal versions of itch, and processing of histamine itch within the human cerebral cortex. The textual content clarifies itch in systemic and dermis sickness, exploring renal itch, uremic pruritus, lichen amyloidosis and extra.
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Additional resources for Itch: Basic Mechanisms and Therapy (Basic and Clinical Dermatology)
This neuron might have been a chemonociceptive neuron that was sensitized by prior noxious heat stimulation of the skin during the Central Neural Mechanisms of Itch 29 examination of other cells in that experiment. Thus its weak histamine response was in all likelihood an eﬀect of the sensitization. III. OTHER SPINAL NEURONS EXCITED BY HISTAMINE The eﬀects of histamine, and also other irritant and noxious chemicals, on the activity of single rat spinal neurons with unidentiﬁed projections have been studied by Carstens (31) and Jinks and Carstens (32).
Meyer RA, Davis KD, Cohen RH, Treede RD, Campbell JN. Mechanically insensitive aﬀerents (MIAs) in cutaneous nerves of monkey. Brain Res 1991; 561: 252–261. Schmidt RF, Schaible HG, Messlinger K, Hanesch U, Pawlak M. Silent and active nociceptors: structure, functions and clinical implications. In: Gebhart GF, Hammind DL, Jensen TS, eds. Seattle: IASP Press, 1994:213–250. Neurophysiologic Basis of Itch 11 12. Schmelz M, Schmidt R, Handwerker HO, Torebjo¨rk HE. Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve ﬁbres.
002, v2 test) (Fig. 3c). Thus, taken together, the data support the conclusion that histamine-sensitive cells are distinct anatomically and physiologically, and therefore form a unique group of STT neurons. The response characteristics of 4 of the 10 histamine-sensitive lamina I STT neurons were altered following stimulation. After activation by histamine, one cell became weakly responsive to noxious mechanical stimulation (pinching with forceps), and another responded to a slow-moving brush swept across its receptive ﬁeld and to punctate stimulation with a ﬁne wire probe.