Download Lentigo Maligna Melanoma: Challenges in Diagnosis and by Kishwer S. Nehal, Klaus J. Busam PDF

By Kishwer S. Nehal, Klaus J. Busam

This publication presents a finished method of the prognosis and administration of cancer of the lentigo maligna subtype, particularly. Authors from a number of fields supply academic details in addition to importantly appropriate, useful, and insightful information to enhance the certainty and administration method of this kind of cancer. The chapters tackle every one element of this cancer starting from scientific presentation, medical and pathologic prognosis, surgical administration, nonsurgical recommendations, and followup.
There is widespread false impression while diagnosing and coping with this kind of cancer as a result of the medical, pathologic, and surgical complexities exact. academic assets actually devoted to this subject are missing presently.

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28. Prieto VG, Shea CR. Immunohistochemistry of melanocytic proliferations. Arch Pathol Lab Med. 2011;135(7):853–9. 29. Plaza JA, Bonneau P, Prieto V, Sangueza M, Mackinnon A, Suster D, et al. Desmoplastic melanoma: an updated immunohistochemical analysis of 40 cases with a proposal for an additional panel of stains for diagnosis. J Cutan Pathol. 2015. 30. Beltraminelli H, Shabrawi-Caelen LE, Kerl H, Cerroni L. Melan-a-positive “pseudomelanocytic nests”: a pitfall in the histopathologic and immunohistochemical diagnosis of pigmented lesions on sun-damaged skin.

Currently, the molecular tests used for diagnosis include cytogenetic methods, such as fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) [37] and possibly gene expression profiling [38, 39]. Mutation analysis is indicated to guide targeted therapy of metastatic melanoma, especially to determine the presence or absence of BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase) V600 codon mutations [40, 41]. Prognostic gene expression panels have also been proposed, but are associated with methodological shortcomings and have not yet been validated [38, 39, 42].

Robinson JK. Margin control for lentigo maligna. J Am Acad Dermatol. 1994;31(1):79–85. 31. Robinson JK. Use of digital epiluminescence microscopy to help define the edge of lentigo maligna. Arch Dermatol. 2004;140(9):1095–100. 32. Chen CS, Elias M, Busam K, Rajadhyaksha M, Marghoob AA. Multimodal in vivo optical imaging, including confocal microscopy, facilitates presurgical margin mapping for clinically complex lentigo maligna melanoma. Br J Dermatol. 2005;153(5):1031–6. 33. Guitera P, Haydu LE, Menzies SW, Scolyer RA, Hong A, Fogarty GB, et al.

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