By Mildred S. Seelig
There's a huge and swiftly transforming into physique of literature at the significance of magazine nesium in biochemical and physiological methods. there's additionally a lot facts that magnesium deficiency, on my own and together with brokers that intervene with its usage, is linked to practical and structural abnormalities of mem branes, cells, organs, and platforms. The manifestations of the alterations attributable to magnesium deficiency rely on its quantity and period and on variable elements. one of the stipulations that raise the danger of magnesium deficiency are (1) meta bolic components that impact the absorption, distribution, and excretion of this mineral; (2) ailment and remedy; (3) physiologic states that raise necessities for food; and (4) dietary imbalances. Excesses of food that intrude with the absorption or raise the excretion of magnesium-such as fats, phosphate, sugar, and nutrition D-can give a contribution to long-lasting relative magnesium deficiency. All were implicated in numerous of the ailments thought of during this ebook. even if their impact at the desire for magnesium is a typical denominator continues to be investigated additional.
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Extra info for Magnesium deficiency in the pathogenesis of disease : early roots of cardiovascular, skeletal, and renal abnormalities
1962). Since high phosphate intake interferes with magnesium, as well as calcium absorption, it is possible that calcium phosphate salts also lowered magnesium levels, and that this might have contributed to the muscle cramps. The first reports of blood magnesium levels during pregnancy were in 1923. 2 mEq/liter among 17 women in their 8th to 40th weeks of pregnancy. 7 by the end of pregnancy. 99 mEq/liter (which was below the values they found in normal nonpregnant subjects), and that the percentage of the total magnesium in the ultrafiltrable fraction was increased.
Already mentioned is the possibility that agents (such as vitamin D or derivatives) that affect magnesium requirements, as well as presenting other toxic potential (Seelig and Mazlen, 1977), can participate. Additionally, in a study of the effect of vitamin D 2 , with and without calcium and phosphorus supplements on success of gestation in rats, Nicholas and Kuhn (1932) found that unlike the test rats the control rats were given fresh green vegetables, yeast, fruits, butter, and cod liver oil and had the best gestations.
Surprisingly, despite the marked fetal damage caused by the deficiency during gestation, the pregnant rats showed only mild signs of magnesium deficiency despite sharp drops in their plasma magnesium levels. The severity offetal damage produced in these studies was greater than in other studies; there might have been concomitant trace element deficiencies. Magnesium defi- 56 CHAPTER 3 ciency (Ij13o of control intake), comparable to that produced in the less severely depleted rats of Hurley et al.