Download Mechanisms of Atrial Arrhythmias: Insights from the by Michael A. Colman PDF

By Michael A. Colman

This thesis describes the advance of biophysically special laptop types of the human atria and torso to check the underlying mechanisms of cardiac illnesses, one of the most universal reasons of morbidity and mortality. this can be a cross-disciplinary venture, concerning basics of cardiac electrophysiology, physics of excitable media, utilized arithmetic and excessive functionality medical computing and visualisation. the writer makes use of laptop types to supply insights into the underlying mechanisms of the genesis of atrial traumatic inflammation and develops novel ideas for the tracking of atrial tachycardia.

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Additional info for Mechanisms of Atrial Arrhythmias: Insights from the Development of a Biophysically Detailed Model of the Human Atria

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It also has the advantage of leaving the tissue intact, and hence allowing it to be used for other purposes. It has been shown using histology that fibrous structure created using DT-MRI is valid [32, 33]. Computed tomography, also known as CT scan, uses a series of x-rays to build up an array of image slices. Like MRI, CT scans can also be used to create geometrical models of anatomy. Micro CT is a relatively new technique which has a higher resolution than CT scans. It can resolve to a small enough degree to pick up fibrous detail, to which an algorithm can be applied to create a model of fibre structure.

This is adapted from [20] into the intracellular space. The SR Ca2+ pump regulated by SERCA then acts to pump Ca2+ back into the SR, restoring the concentration of Ca2+ ions within it. Ca2+ is also extruded from the intracellular space into the extracellular space via the sarcolemmal Ca2+ pump (ICaP) and the sodium-calcium exchanger (INaCa). This cycle is illustrated in Fig. 7a. The cyclic change to the intracellular Ca2+ concentration is known as the calcium transient. A typical Ca2+ transient associated with an AP, and the tension development as a result is shown in Fig.

Finally is the T wave, which is due to repolarisation of the ventricles. Due to ventricular APD heterogeneity, it is usually in the same orientation as the QRS complex. Fig. 14 Schematic of an ECG. A schematic example of a typical ECG waveform. The different waves and intervals are labelled. 2 Analysing ECGs There are various properties of the ECG which can be analysed to indicate either healthy or diseased states in the heart. Below are described just a few of these properties. I. PR interval The PR interval is the time between the start of the P-wave and the first deflection of the QRS complex.

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