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By Russel O. Potts

Presents an up to date and significant exam of biophysical thoughts utilized in the research of molecular mechanisms underlying transdermal drug supply in addition to a actual and chemical review of the stratum corneum important for the enhancement of percutaneous drug shipping. displays the hands-on adventure of demonstrated and novel researchers within the box.

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Extra resources for Mechanisms of Transdermal Drug Delivery

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Scanning and freeze-fracture electron microscopy have supplemented transmission electron microscopy by supplying three-dimensional representations of the transport pathways within the SC. Confocal and scanning electrochemicalmicroscopy of fluorescent and electmactive species, respectively, have provided complementaryinformation to that from the other microscopy techniques. Both these newer methods have the advantage of using the skin without fixation, thus avoiding possible artifacts associated with its chemical preservation.

Horinouchi, M. Percutaneous absorptionofelcatoninandhypocalcemiceffectinrat. Chem. Pharm. Bull. 39M9-453, 55. Hofland, H. ,Bouwstra, J. , Bodd6, H. , Spies, F. and Junginger, H. E. Interactionsbetweenliposomesand human stratumcorneuminvitro:Freeze fractureelectronmicroscopicalvisualizationandsmallanglex-rayscattering studies. Br. J. Dermatol. , et al. Visualization of diffusion pathways across the stratum corneum of native and in-vitro-reconstructed epidermis by confocal laser scanning microscopy.

Bouwstra et al. 44 II. GENERALPRINCIPLES OF STRUCTURE DETERMINATION BY X-RAY DIFFRACTION The general principles of x-ray diffraction are described well in a number of standard texts (Rhodes, 1993; Woolfson, 1970; Warren, 1969). We focus here the essential ideas necessaryfor understanding diffraction from the stratum corneum. The x-rays incident a sample interact with the electron clouds of thesample’smoleculesand are scattered onto adetector,such as photographic film, that records the positions and intensities of the scattered x-rays.

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