By Gregory N. Stephanopoulos, Aristos A. Aristidou, Jens Nielsen
Metabolic engineering is a brand new box with purposes within the creation of chemical substances, fuels, fabrics, prescribed drugs, and drugs on the genetic point. The field's novelty is within the synthesis of molecular biology thoughts and the instruments of mathematical research, which enable rational choice of goals for genetic amendment via measurements and keep an eye on of metabolic fluxes. the target is to spot particular genetics or environmental manipulations that lead to advancements in yield and productivities of biotechnological strategies. Key good points of the e-book are pathway integration and the point of interest on metabolic flux as a basic determinant of phone body structure. The ebook retains mathematical complexity to a minimal, and offers a thesaurus of organic phrases to facilitate use of the e-book by way of a broader spectrum of readers. an internet web page exists to speak updates of the codes and homework difficulties. Key beneficial properties * Demonstrates metabolic engineering in motion with various examples of pathway amendment * comprises tools for choosing key enzymes in metabolic networks * incorporates a entire evaluation of metabolic biochemistry * Discusses metabolic law on the gene, enzyme, operon, and telephone degrees * Explains ideas of stoichiometry, kinetics, and thermodynamics of metabolic pathways * Minimizes mathematical complexity * hyperlinks to an internet web page to speak updates of the software program code and homework difficulties
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Extra info for Metabolic Engineering: Principles and Methodologies
Using this equation Henriksen et al. 2. 0 the accumulation is high (about 100-fold). For a given total extracellular acid concentration, the concentrations of both forms of the acid on each side of the cytoplasmic membrane can be calculated using eq. (2), from which the mass flux of acid across the 2 Reviewof Cellular Metabolism 31 membrane can be calculated using eq. (1). Because the net outflux of dissociated acid equals the net influx of undissociated acid, the result of acid transport is a net influx of protons, which have to be re-exported by the plasma membrane ATPase in order to maintain a constant intracellular pH.
Charkrabarty, A. M. (1981). Plasmid-assisted molecular breeding: new technique for enhanced biodegradation of persistent toxic chemicals. Science 214, 1133-1135. MacQuitty, J. J. (1988). Impact of biotechnology on the chemical industry. ACS Symposium Series 362, 11-29. Nerem, R. M. (1991). Cellular engineering. Annals of Biomedical Engineering 19, 529-545. Stephanopoulos, G. & Vallino, J. J. (1991). Network rigidity and metabolic engineering in metabolite overproduction. Science 252, 1675-1681.
In the context of metabolic networks this has already contributed to increased attention to problems related to flux measurement in vivo. For information networks, it can similarly define analytical needs for elucidating and quantifying the fluxes of information processed through protein-mediated reaction cascades. As the benefits of such measurements become clear in the framework provided, they may drive the development of such instrumentation. As mentioned in the previous section, elucidation of the flux control structure of metabolic pathways offers tremendous opportunities for the rational design of the optimal enzymatic profile of a cellular catalyst.