Download Methodological Challenges in Biomedical HIV Prevention by Stephen W. Lagakos, Alicia R. Gable PDF

By Stephen W. Lagakos, Alicia R. Gable

The variety of humans contaminated with HIV or dwelling with AIDS is expanding at extraordinary premiums as quite a few scientists, enterprises, and associations look for leading edge suggestions to struggling with and fighting the affliction. on the request of the invoice & Melinda Gates origin, Methodological demanding situations in Biomedical HIV Prevention Trials addresses methodological demanding situations in late-stage nonvaccine biomedical HIV prevention trials with a particular specialize in microbicide and pre-exposure prophylaxis trials. This ebook recommends a couple of how one can enhance the layout, tracking, and research of late-stage scientific trials that evaluation nonvaccine biomedical interventions. The targets comprise picking a invaluable approach to intervention, bettering quantification of the effect, effectively assessing the consequences of utilizing such an intervention, and decreasing biases which could bring about fake optimistic trial effects. in response to Methodological demanding situations in Biomedical HIV Prevention Trials, the necessity to establish a variety of potent, sensible, and cheap preventive suggestions is important. even if a good number of promising new HIV prevention options and items are at present being established in late-stage scientific trials, those trials face a myriad of methodological demanding situations that gradual the speed of study and restrict the facility to spot and entirely review potent biomedical interventions.

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Bailey, R. , S. Moses, C. B. Parker, K. Agot, I. Maclean, J. N. Krieger, C. F. Williams, R. T. Campbell, and J. O. Ndinya-Achola. 2007. Male circumcision for HIV prevention in young men in Kisumu, Kenya: A randomised controlled trial. Lancet 369(9562): 643-656. Dunkle, K. , R. K. Jewkes, H. C. Brown, G. E. Gray, J. A. McIntryre, and S. D. Harlow. 2004. Gender-based violence, relationship power, and risk of HIV infection in women attending antenatal clinics in South Africa. Lancet 363(9419):1415-1421.

Palacios, and T. J. Coates. 2007. Innovative approaches to cohort retention in a community-based HIV/STI prevention trial for socially marginalized Peruvian young adults. Clinical Trials 4(1):32-41. , M. Rusizoka, H. Weiss, K. Mugeye, K. Baisley, J. Changalucha, D. Everett, C. Tanton, T. Clayton, D. Ross, and R. Hayes. 2007. Impact of HSV-2 suppressive therapy on HIV incidence in HSV-2 seropositive women: A randomised controlled trial in Tanzania. Paper read at Fourth International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, Sydney, Australia.

Prentice, R. L. 1989. Surrogate endpoints in clinical trials: Definition and operational criteria. Statistics in Medicine 8(4):431-440. Robinson, K. , C. R. Dennison, D. M. Wayman, P. J. Pronovost, and D. M. Needham. 2007. Systematic review identifies number of strategies important for retaining study participants. Journal of Clinical Epidemiology 60(8):757-765. UNAIDS. 2000. Ethical considerations in HIV preventive vaccine research. Geneva, Switzerland: UNAIDS. UNAIDS. 2007. 2007 AIDS Epidemic Update.

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