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Extra resources for Methods in Bioengineering: Alternative Technologies to Animal Testing (The Artech House Methods in Bioengineering)
Sorger, and K. F. Jensen, “Cells on Chips,” Nature, Vol. 442, No. 7101, 2006, pp. 403–411. Toepke, M. , and D. J. Beebe, “PDMS Absorption of Small Molecules and Consequences in Microfluidic Applications,” Lab Chip, Vol. 6, No. 12, 2006, pp. 1484–1486. Lau, Y. , “Ex Situ Inhibition of Hepatic Uptake and Efflux Significantly Changes Metabolism: Hepatic Enzyme-Transporter Interplay,” J. Pharmacol. Exp. , Vol. 308, No. 3, 2004, pp. 1040–1045. 6          Summary Brown, H.
Wt. 2 PAMPA permeability and human absorption. 5 21 50 50 36 71 45 32 83 100 35 79 87 4 100 100 39 98 81 100 100 60 99 100 29 100 16 100 100 60 31 63 92 100 18 100 90 54 100 100 23 100 82 23 98 100 75 97 100 71 99 56 100 100 16 100 96 100 43 99 90 39 94 Source: [3, 42, 43]. 1 Cell culture and PAMPA systems It is generally accepted that the Caco-2 cell system is used as an intestinal permeability screen during lead optimization in the pharmaceutical industry. This type of early screening would provide medicinal chemists with guidance in choosing more favorable chemotypes.
Lastly, the preparation of fully differentiated Caco-2 cells generally requires a 3-week cell culture period with eight to ten cell feedings. A fully automated system for cell seeding and feeding can be used for industrial high-throughput screening purposes; however, for more limited use, this labor-intensive cell culture process could become a rate-limiting factor. The cell preparation time can be substantially reduced by using an available coating material and supplemented growth medium. The generation of a functional monolayer in a shorter cell culturing period not only increases the productivity, but also decreases the chance of having contamination.