By Chandra K. Dixit, Ajeet Kaushik
This publication describes novel microtechnologies and integration options for constructing a brand new classification of assay platforms to retrieve wanted well-being info from sufferers in real-time. the choice and integration of sensor elements and operational parameters for constructing point-of-care (POC) also are defined intimately. the fundamentals that govern the microfluidic routine and the recommendations and techniques at present hired for fabricating microfluidic platforms and integrating biosensors are completely lined. This e-book additionally describes the appliance of microfluidics within the box of mobile and molecular biology, unmarried mobilephone biology, affliction diagnostics, in addition to the commercially to be had structures which have been both brought or have the potential for getting used in examine and improvement. this is often an incredible publication for supporting biologists in figuring out the basics and purposes of microfluidics.
This e-book additionally:
Describes the preparatory tools for constructing third-dimensional microfluidic buildings and their use for Lab-on-a-Chip design
Explains the importance of miniaturization and integration of sensing parts to boost wearable sensors for point-of-care (POC)
Demonstrates the applying of microfluidics to lifestyles sciences and analytical chemistry, together with sickness diagnostics and separations
Motivates new principles on the topic of novel structures, valving expertise, miniaturized transduction tools, and equipment integration to increase subsequent iteration sequencing
Discusses destiny clients and demanding situations of the sector of microfluidics within the components of lifestyles sciences usually and diagnostics in particular
Read Online or Download Microfluidics for Biologists: Fundamentals and Applications PDF
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Additional info for Microfluidics for Biologists: Fundamentals and Applications
A) In an inertial frame of reference the observer is out of the rotating disk. The stationary observer will see the rolled ball following a straight path. (b) However, when observer stands on the same rotating disk on which the ball was rolled then to this rotating observer ball will seem to follow a curved path outwards. This perspective of curving of the path of ball is Coriolis effect. (c) This effect is used in rotating microfluidics for separating particles in a fluid plug of length ‘l’. In this plug, the particle will experience an outward centrifugal force normal to the rotation axis and an outward force normal but opposite to the direction of the rotation, as depicted in ‘(c)’.
In order to 2 Microfluidics Overview 43 Fig. 7 Dimensional micro-channel arrays within PDMS blocks using thin circular copper wires. (Reproduced from Singh et al.  with permission from the Institute of Electrical and Electronics Engineers) realize high aspect ratio micro-channels, thin wires of copper etched to a diameter of 50–80 μm were inserted between opposing holes in a mold box with a special tweezers and provided with finite tension using a special jig developed for this purpose. PDMS commercially available in a 10:1 ratio of a silicone rubber to curing agent was poured into the plastic box over the wires and replicated the wire array.
The first ever peristaltic micro-pump was patented by Smits in 1989. This was a silicon based device fabricated using already established MEMS fabrication technology, and was provided with a set of piezoelectric valves which would deflect and squeeze out on chambers in a sequential manner. 6 m H2O. Further, it was observed that the discharge rate varied linearly with the back pressure till a threshold frequency of 15 Hz was met beyond which it started to fall 2 Microfluidics Overview 49 Fig. 12 Pumping sequence of the peristaltic pump (Reproduced from Smits  with permission from the Elsevier) off.