By Beth A. Goins, William T. Phillips
The first source of its variety, this publication covers state of the art learn at the use of nanoparticles for in vivo diagnostic scientific imaging and treatment. It discusses quite a few nanoparticles, together with quantum dots, carbon nanotubes, dendrimers, gold nanoshells, steel nanorods, micelles, liposomes, polymers, MRI iron oxide debris, and microbubbles. Examples within the e-book contain multifunctional nanoparticles that designed for multimodality imaging and simultaneous diagnostic and remedy (theranostic) applications.
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The strong T1 effect was presumably due to the lack of internalization of USPIO since L6 is a noninternalizing antibody. The nanoparticles used in the study also had a relatively low R2/R1 ratio. The internalization of iron oxide nanoparticles in cells is usually accompanied by a decrease in T1-weighted contrast due to limitations in water diffusion and strong T2* effects due to USPIO clustering inside the intracellular organelles. 5T, SE TR/TE=300/6 ms) of LX-1 (human small cell lung carcinoma) tumors implanted in the brain as a model of lung cancer metastasis.
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