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1983) in Development of Auditory and Vestibular Systems, ed. Romand, R. (Academic, London), pp. 309–333. 46. D. & Choo, D. ) 125, 11–20. 47. , Dickson, C. & Ylikoski, J. Neurosci. 20, 6125–6134. 48. H. P. (1995) Science 267, 685–688. 49. , Kyin, T. & Crenshaw, E. B, 3rd (1998) Hear. Res. 120, 77–85. 50. C. Neurosci. 19, 5980–5989. 51. , et al. (1999) Science 285, 1408–1411. 52. , et al. (1997) Nat. Genet. 15, 157–164. 53. , El-Amraoui, A. & Petit, C. (1998) Dev. Dyn. 213, 486–499. 54. L. (1994) Mol.

Neurol 331, 75–96. 88. D. & Rubel, E. W (1993) Hear. Res. 71, 125–136. 89. G. & Rubel, E. W (1990) Hear. Res. 48, 161–182. 90. , Stoots, S. F. (1992) Exp. Neurol. 115, 18–22. 91. Wang, Y. & Raphael, Y. (1996) Hear. Res. 97, 11–18. 92. P. A. (1997) Hear. Res. 113, 207–223. 93. C. K. (1985) Neuroscience 14, 255–276. 94. C. K. (1985) Neuroscience 14, 277–300. 95. S. & Rubel, E. W (1999) J. Comp. Neurol. 406, 183–198. 96. Raphael, Y. (1992) J. Neurocytol. 21, 663–671. 97. K. M. (1996) Acta Otolaryngol 116, 257–262.

CProx1 protein is highly expressed in prosensory and proneural regions of auditory and vestibular portions of the avian otocyst, and expression is down-regulated by the time hair cell differentiation is complete. Interestingly, cProx1 protein becomes highly and transiently re-elevated in the mature auditory epithelium after experimental damage, first in progenitor cells and later in hair cells. Prospero and its homologs have emerged as an interesting set of transcription factors with diverse roles.

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