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By Maysie J. Hughes

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Further­ more, the neurochemistry of these regions is becoming available with the 2. Brain Stem a n d Cerebellar M e c h a n i s m s 43 advent of new sensitive techniques. Obviously, a large gap exists between the knowledge currently held a n d a full u n d e r s t a n d i n g of how the b r a i n orchestrates the autonomic nervous system. A close a n d continued anal­ ysis of the physiology and synaptology of the interconnections of these areas seems warranted. F u r t h e r m o r e , more emphasis should be placed on the role of the new peptides, such as the endorphins, as well as some of the less investigated amines a n d a m i n o acids.

H e l k e , C. , a n d Gillis, R . A. (1977). C a r d i o v a s c u l a r responses to electrical s t i m u l a t i o n of t h e m e d u l l a r y r a p h e a r e a of t h e cat. Brain Res. 128, 141-145. A g h a j a n i a n , G. K. (1978). T o l e r a n c e of locus c o e r u l e u s n e u r o n e s t o m o r p h i n e a n d s u p p r e s s i o n of w i t h d r a w a l r e s p o n s e b y c l o n i d i n e . Nature (London) 276, 186-188. A l e x a n d e r , R . S. (1946). T o n i c a n d reflex f u n c t i o n s of m e d u l l a r y s y m p a t h e t i c c a r d i o ­ v a s c u l a r c e n t e r s .

T h . , a n d S c h m i t t , H . (1975). L o c a l i z a t i o n of t h e c e n t r a l s y m p a t h o - i n h i b i t o r y effect of a n a r c o t i c analgesic a g e n t , f e n t a n y l , in cats. Eur. J. Pharmacol 33, 91-97. D a y , M . , a n d R o a c h , A. G. (1977). C a r d i o v a s c u l a r effects of c a r b a c h o l a n d o t h e r c h o l i n o m i m e t i c s a d m i n i s t e r e d i n t o t h e c e r e b r a l ventricles of conscious cats. Clin. Exp. Pharmacol. Physiol. 4, 431-442.

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