Download Newer methods of nutritional biochemistry Volume 3, with by A A (ed.) Albanese PDF

By A A (ed.) Albanese

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The poor protein intake of the Bush Negroes in Kabel was manifest in low urea: total nitrogen and urea: creatinine ratios; Dutch children from Moengo on a European diet showed the highest urea:creatinine ratios. However, no difference in urea to total nitrogen ratios was observed in any of the study groups. The authors concluded that the results paralleled the composition of the diets. V. 5 Protein intake (gm/kg/day) FIG. 10. Ratio of urea nitrogen to creatinine in fasting urine at controlled levels of protein intake.

3 From Jagenburg (43). H = human milk; C = cow's milk; V = varied diet. Mean values. tissue mass by expressing the data as a function of urinary creatinine (55, 56). The effect of dietary nitrogen on amino acid excretion can be seen in Fig. 6. This effect was less apparent in subject J. , who had undergone 10 days of treatment before he was placed on the study. The isonitrogenous substitution of maize for milk ( < 500 mg of nitrogen per kilogram per day) did not affect the trends of excretion appreciably except for the aminoaciduria in infant J.

12). The fatty acid chain is derived from glycine, the guanidine nucleus from arginine, and the glycocyamine thus synthesized is methylated by transfer of the labile methyl group from methionine. Creatinine is readily eliminated by the kidneys, and its normal concentration in urine is considerably greater than in serum (Table I X ) . 5 mg/100 ml (86, 87). The creatinine output is greater in men with well-developed muscles than in men with small muscles, in women, or children (Fig. 13). 23 1. URINARY EXCRETION OF AMINO ACIDS '® NH HN=C/ \N—CH2—COOH CH3 H 2 N-CH 2 -COOH Creatine phosphate Glycine ATP NH2 HN=C \N —(CH2)3—CH NH2 COOH " c I N= CH2—COOH & NHo \N - C H 2 - C O O H CH3 Guanidoacetic acid Arginine NH2 HN=C Creatine / / H3C—S—CH2—CH2—CH—COOH HN—CO Methionine HN=C^ I N-CH2 CH, Creatinine F I G .

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