Download NLR Proteins: Methods and Protocols by Francesco Di Virgilio, Pablo Pelegrín PDF

By Francesco Di Virgilio, Pablo Pelegrín

This quantity offers a legitimate foundation for the molecular research of NLR functionality in healthiness and affliction. Chapters specialize in of innate immune receptors, “atypical” inflammasomes, biochemical and novel bioluminescence thoughts for the size of IL-1b, bioluminescent probe, biochemical and microscopy recommendations, ideas to degree caspase-1 activation, phone loose platforms for the examine of inflammasome functionality, and inflammasome activation. Written within the hugely winning Methods in Molecular Biology series layout, chapters contain introductions to their respective subject matters, lists of the required fabrics and reagents, step by step, quite simply reproducible laboratory protocols, and tips about troubleshooting and averting identified pitfalls.


Authoritative and state-of-the-art, NLR Proteins: tools and Protocols goals to make sure profitable leads to the extra examine of this important field.

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NEMO, another regulator of NFκB, is also recruited and facilitates TAK1 recruitment to the complex. Formation of this complex promotes phosphorylation and targeting of the IκK complex subunits for proteasomal degradation, promoting release of NFκB [119, 123]. Activation of NOD1 and NOD2 also triggers activation of the MAPK pathway although this has received less attention. Finally, NOD receptors have been shown to activate the IRF pathway (Fig. 3b). NOD2 induces type-I IFN secretion upon recognition of viral single-stranded RNA or during infections with respiratory syncytial virus and influenza virus [155].

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1038/nature07830 30. Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124(4):783–801. 1016/j. 015 31. Matsushima N, Tanaka T, Enkhbayar P, Mikami T, Taga M, Yamada K, Kuroki Y (2007) Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate Toll-like receptors. BMC Genomics 8:124. 1186/1471-2164-8-124 32. Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, Hayden MS, Hieny S, Sutterwala FS, Flavell RA, Ghosh S, Sher A (2005) TLR11 activation of dendritic cells by a protozoan profilin-like protein.

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