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By Humberto Foyaca-Sibat (Ed.)

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Table 5 summarized several drugs under investigation for their efficacy towards Tuberous Sclerosis Complex. The discovery of mTOR (mammalian target of rapamycin) pathway upregulation in tuberous-sclerosis-associated tumours presents new possibilities for treatment strategies. , 2008). Sirolimus is a macrolide antibiotic that acts as an mTOR kinase inhibitor. It is isolated from Streptomyces hygroscopicus. Sirolimus and its analogs have been shown to make the dysregulated mTOR pathway return to normal in cells that lack TSC1 or TSC2.

Values of score ESS and statistical parameters in cotrol group and group of patients with epilepsy. p t-test Kruskal-Wallis Kolmogorov-Smirnov 0,00261226* 0,047123469* 0,000152915* Table 4. Statistical comparison of values ESS by Students t-test, Kruskal-Wallis test a Kolmogorov-Smirnovov test. All result are statistically significant. 2 Changes in sleep architecture In control group and group of patients with epilepsy statistical parameters as effectivity of sleep, amount of NREM S1, S2, S3+4, REM, latency to NREM S1 and latency to REM sleep were evaluated.

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