Download Percutaneous absorption: by Robert L. Bronaugh, Howard I. Maibach PDF

By Robert L. Bronaugh, Howard I. Maibach

In view that e-book of the second one version in 1989, a variety of options have happened that have an effect on the best way scientists examine concerns within the box of percutaneous absorption. targeting contemporary advances in addition to updating and increasing the scope of subject matters lined within the earlier version, Percutaneous Absorption, 3rd variation offers thorough insurance of the skin's function as a massive portal of access for chemical compounds into the physique. Assembles the paintings of approximately eighty experts-30 greater than the second one Edition-into a unified, complete quantity that includes the most recent rules and examine! whole with approximately six hundred drawings, photos, equations, and tables and greater than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, 3rd variation info ·the utilized biology of percutaneous penetration ·factors that have an effect on pores and skin permeation, comparable to age, autos, metabolism, hydration of epidermis, and chemical constitution ·in vivo and in vitro innovations for measuring absorption, reading elements influencing technique equivalent to animal types, volatility of attempt compound, a number of dosage, and synthetic membranes ·procedures to be used in transdermal supply, exploring issues akin to results of penetration enhancers on absorption, optimizing absorption, and the topical supply of gear to muscle mass And provides new chapters on ·mathematical types ·cutaneous metabolism ·prediction of percutaneous absorption ·in vitro absorption method ·dermal decontamination ·concentration of chemical compounds in epidermis ·transdermal drug supply ·mechanisms of absorption ·safety assessment of cosmetics ·absorption of substances and beauty elements ·nail penetration Emphasizes human applications-particularly beneficial for pharmacists, pharmacologists, dermatologists, beauty scientists, biochemists, toxicologists, public overall healthiness officers, brands of beauty and toiletry items, and graduate scholars in those disciplines! a useful reference resource for readers who have to stay alongside of the newest advancements within the box, Percutaneous Absorption, 3rd version can also be a good experimental advisor for laboratory group of workers.

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Additional info for Percutaneous absorption: drugs--cosmetics--mechanisms--methodology

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Barry 499 31 Stratum Corneum and Barrier Performance: A Model Lamellar Structural Approach Hamid R. Moghimi, Brian W. Barry, and Adrian C. Williams 515 32 Role of In Vitro Release Measurement in Semisolid Dosage Forms Vinod P. Shah, Jerome S. Elkins, and Roger L. Williams 555 33 Percutaneous Absorption of Salicylic Acid, Theophylline, 2,4-Dimethylamine, Diethyl Hexyl Phthalic Acid, and p-Aminobenzoic Acid in the Isolated Perfused Porcine Skin Flap Compared to Humans In Vivo Ronald C. Wester, Joseph L.

2B), and when the vehicle cannot be considered well stirred. We examine each of these models in terms of expressions for amount penetrating, flux, and, where possible, summary parameters such as mean absorption time, normalized variance, peak time for flux, and maximum flux. A. In Vitro Skin Permeability Studies with a Constant Donor Concentration and Sink Receptor Conditions Most in vitro skin permeability studies are carried out assuming that both a) the concentration of solute in a vehicle applied to the skin and b) the sink Page 6 * Page 7 conditions provided by the receptor remain constant over the period of the study.

Accordingly, the amount of solute absorbed across the skin Q(t) at various times t is defined in the Laplace domain as: (37) Of particular interest in this overview is the case of a constant donor concentration (infinite donor) and sink receptor. Q(s) is then defined by: (38) Page 18 Figure 8A shows the effect of kc (as defined by a = kctd) on Q(t) versus time profile. Note that, at long times, the linear portion of Q(t) [defined by Eq. (38)] versus t profile describes a steady-state flux Jss and lag time (lag): (39) (40) Thus, both the slope and lag of the steady-state portion of a Q(t) versus t plot depend on kc.

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