Download Pharmacogenomic Testing in Current Clinical Practice: by Alan H. B. Wu PDF

By Alan H. B. Wu

While the elemental ideas of customized drugs and pharmacogenomics has been lined by way of quite a few texts, there are none to this point that specializes in the explicit checks themselves which are in present medical perform and people who are being proposed for implementation within the close to destiny. Pharmacogenomic checking out in present scientific perform: Implementation within the medical Laboratory focuses nearly fullyyt at the specifics of every try out that's had to enforce those checks right into a scientific laboratory. This quantity offers the 1st compilation of the checks at present in regimen scientific use. The bankruptcy authors of this precise and priceless identify contain quite a number popular specialists and investigators who've performed the basic medical trials essential to justify pharmacogenomic trying out this day. The e-book is split into 4 components: simple thoughts, particular Pharmacogenomic ambitions, medicines that reason not on time allergic reaction, and Miscellaneous medications. each one writer offers a pharmacologic heritage at the objective drug, the necessity for pharmacogenomic checking out, and the way effects could be translated into medical judgements. the place acceptable, case reports are given to demonstrate average medical eventualities. an in depth bibliography is equipped in order that the reader can discuss with the unique reviews. This well-designed source will entice medical laboratory administrators who're considering or assigned the duty of building a pharmacogenomics laboratory and quite a lot of clinicians who needs to interpret result of checking out. centred and immensely invaluable, Pharmacogenomic checking out in present medical perform: Implementation within the medical Laboratory is a well timed and extraordinary contribution to the literature and should be instrumental in defining this speedily transforming into field.

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Additional info for Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory

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1) that provides detection of CYP2D6 and CYP2C19 gene variants. This test is FDAcleared for IVD use and is currently offered by several major reference laboratories. Affimetrix chips are oligonucleotide arrays that contain hundreds of thousands of oligonucleotide probes anchored on glass support at very high density. The basis of this technology is hybridization of the target DNA to the microarray and generation of fluorescent signal. A workstation provided by Affymetrix is necessary to collect data and perform the analysis.

B) The Verigene Processor is comprised of four independent test modules controlled by the Verigene Reader. It facilitates the wet chemistry inside the test cartridge (c). Test processing in this module relies on offline nucleic acid extraction. (d) The Verigene Processor SP possesses all of the same test processing functionality and components as the regular processor but additionally provides capabilities to extract DNA directly from the specimen. These additional functions require the following consumables: a Verigene Extraction Tray and Verigene Tip Holder Assembly (not shown).

1 Hypothetical cost-effective pharmacogenomic (PGx) models following angioplasty with stent placement: Drug expenses model for clopidogrel vs. 62/day for clopidogrel, from Cohen DJ. B. 2 Hypothetical cost-effective pharmacogenomic (PGx) models following angioplasty with stent placement: Clinical outcomes model for standard vs. high-dose clopidogrel Measuring parameter No PGx (75 mg dosage) PGx (150 mg dosage) Number of subjects 100 100 CYP2C19 carrier rate NA 25% PGx testing ($150 ea) NA $15,000 Adverse event rate a 12% (12 patients) 8% (8 patients) Annual DRG #122 for AMI b $240,000 $160,000 Clopidogrel annual drug costs $168,000 $210,000c Total $408,000 $385,000 Savings $23,000 a Rates taken from Mega et al.

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