By Ivan Kempf, Volker Alt, Kwok-Sui Leung, H.J.T.M. Haarman, Gilbert Taglang, Hartmut Seidel, Reinhard Schnettler
The 3rd quantity of the "Practice of Intramedullary Locked Nails" areas a different specialise in fresh developments in realizing the biology of fracture therapeutic of lengthy bones, the rising applied sciences that extra improve the minimally invasive nature of closed remedy of fractures, and the supply of assorted surgical recommendations in intramedullary fixation. the appliance of recent know-how in prevention of an infection and alertness of the intramedullary fixation of fractures in pediatric and adolescent sufferers also are defined. The participants to this quantity are from diversified recognized trauma facilities and are pioneer surgeons within the improvement and perform of intramedullary locked nails.
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Extra resources for Practice of Intramedullary Locked Nails: New Developments in Techniques and Applications
Transverse fractures in the middle of the diaphyses were created in the right tibiae and basic FGF was injected into the fracture sites at a single dose of 200 lg. The fractures were stabilized by intramedullary nails. The time course of changes in callus volume and morphology of the fracture sites was evaluated at weeks 2, 4, 8, 16, and 32 after treatment, and the fracture strength was analyzed at weeks 16 and 32. At week 2, a radiogram of the fracture site showed obvious membranous ossification in the group injected with basic FGF.
Two IGFs have been identified: IGF-I and IGF-II. Although IGF-II is the type most abundant in bone, IGF-I has been found to be more potent and has been localized in healing fractures in rats and humans. Therefore, experimental studies focused attention on both growth factors for their strict connection in inducing the final effects on skeletal growth and bone formation. In Vivo Results Bak et al. 0 mg/kg per day) on fracture healing in rats. Animals received either no injection or twice-daily injections of GH or saline solution (control group), beginning 7 days before the fracture and continuing until the animals were killed, 40 days after the fracture.
Using a point-counting method the authors determined the amount of bone, cartilage and fibrous tissue in the calluses. The animals treated with stable plating showed a callus composed almost entirely of bone, with no effect from the 60-ng injection and abundant callus formation in the animals treated with the 600-ng injections but with no increases in bone content. In contrast, animals with an unstable mechanical construct had minimal bone and cartilage formation after treatment with either 60 or 600 ng of TGF-b2.