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By A. Benakis (auth.), Alberto Frigerio (eds.)

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MINO· 3·METHYl·PHENOXY· ler ·BUTYL· ... 29' 2· "'MINO· 3 ·METHYL· PHENOXY· ler BUTYL' ... MINO·PROP... & pH 11 ' CH3 OH /CH'l I OCH2-CH- CH2-NH-C-CH) pH 2 URINE , CH3 OC~-CH-CH2-NH-C-CHl Z ... MI 1305 04 Z ... MI 1305 CH3 ~ , CH 3 OCH2-CH-CH2-NH-C-Cf<3 ON02 h 048 2-NITRO·3-METHYL· PHENOXY. :: FIG. 6. Metabolites in male dog. 37 2-NTAO-3-UETHYL- .... Y-_ .. 8UTYL-~ ... -AMINO - -..... 101 0 OCW2-CH-CH:I-ICW-CH:I-CW3 OWOz ~cw, FIG. 7. Metabolites in female dog. These were ZAMI 1305 and 2-amino-3-methyl-phenoxy-ethylamino-propan-2-ol in serum, while in urine, in addition to these two metabolites we found 2-nitro-3-methyl-phenoxy-acetic acid and 2-nitro-3-methyl-4,6-dihydroxy-ter buthylamino-propan-2-ol.

Paud1er, J. Het. , 1970, 7, 639. 15) H. Zimmer, R. -J. Kokosa. D. Garteiz. V. Hess and A. Litwin, J. Med. , 1975, 18, 1031. H. G. Dayton, Drug Metab. , 1977, ~, 283. 17) Life Science Research, internal report, 1976. 18) G. Pifferi, F. Parravicini, G. Scarpitta and C. Semeraro, VIth Int. , 1978. MASS SPECTROMETRIC CHARACTERIZATION OF SYDNOCARB ® AND ITS MAJOR METABOLITES IN RAT J. Tamas~, M. Polgar", G. Czira~ and L. Vereczkey" ~ Hungarian Academy of Sciences, Budapest; .. Gedeon Richter Ltd ••Budapest, Hungary INTRODUCTION Sydnocarb, N-phenylcarbamoyl-3-(S-phenylisopropyl)-sydnonimine (1) is a new psychostimulator.

Fates of this substance in animals of different species and sexes. The aim of this study was to identify the metabolites in biological fluids of dogs and rats of both sexes and also to check whether some of the metabolites had pharmacological activity, which is the case for many metabolites of other 8-b1ocking drugs. The drug and its metabolites were identified by thin layer chromatography (TLC) coupled with mass-spectrometry (MS), while the serum levels and urinary recovery were quantified by gas-chromatography (GLC) of a f1uorated derivative after the peak had been identified by gas-chromatography-mass-spectrometry (GLC/MS).

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