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By J.J. Broerse, T.J. Macvittie

`...a ``must'' within the library of scientists, biologists and physicists who're curious about TBI utilized to medication malignant diseases.'
Blut, 51:4 (1985)

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Extra info for Response of Different Species to Total Body Irradiation

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C. MACKS PAR-A Code for Calculating Partial Kerma, Quality and Cell Inactivation Factors. SAI-155-03-0900-01 (1983, to be published). 11. , ed. Radiobiological Factors in Manned Space Flight. National Academy of Sciences, Publication 1487 (1967). 12. P. V. uniform exposures of the mammal. ** *Northwestern University, Chicago, IL, USA. **Radiobiological Institute TNO, Rijswijk, The Netherlands. Introduction The susceptibility of human beings to total body irradiation (TBI) can be estimated approximately from experience obtained in nuclear warfare, in accidents with the peaceful use of nuclear energy and in clinical studies employing TBI in cancer patients.

Groups of 10 or more (mice, rats) or of 4 or more (dogs, monkeys) were tested for each TBI dose. 0 Gy. v. within 30 hours after TBI as a monocellular suspension. The minimal number of bone marrow cells required for rescue of 50% of the animals after TBI was determined by titration of the dose of bone marrow cells. Bone marrow cell doses differed by a factor 2. Animal group size was ten or more in mice and rats and four or more in dogs and monkeys. Results The LD 0 for the bone marrow (BM) syndrome and the gastrointestinal (GI) syndr6me was determined in all four species.

Pp. 349-364, Springer Verlag, Berlin. Zoetelief, J. 1981. Dosimetry and biological effects of fast neutrons. Thesis, Amsterdam. orphic Pbantoas Dean C. Kaul 1 and William H. , 21701 E. , Suite 819, Schaumburg, Illinois 60195, 1200 Prospect St. O. Box 2351), La Jolla, California 92038, USA. Science Applications, Inc. (SAl) has performed calculations of marrow dose and marrow cell survival in anthropomorphic phantoms for the Defense Nuclear Agency (1) and for the Bundeswehr (2,3). That work has recently been expanded to include dose calculations for all organs in a family of Japanese anthropomorphic phantoms.

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