By Didier Raoult, Philippe Parola
Книга Rickettsial illnesses Rickettsial DiseasesКниги Медицина Автор: Didier Raoult, Philippe Parola Год издания: 2007 Формат: pdf Издат.:Informa Healthcare Страниц: four hundred Размер: 4,9 ISBN: 0849376114 Язык: Английский0 (голосов: zero) Оценка:The purely on hand connection with comprehensively talk about the typical and weird different types of rickettsiosis in over 20 years, this publication will supply the reader a whole evaluate at the bacteriology, transmission, and pathophysiology of those stipulations. Written from specialists within the box from Europe, united states, Africa, and Asia, experts examine particular pathogens on the epidemiological, microbiological, and molecular degrees, and talk about the newest developments within the prognosis, administration, and therapy of rickettsial illnesses.
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Changes in the adherens junctions of human endothelial cells infected with spotted fever group rickettsiae. Virchows Arch 2005; 446:379–382. 9. Davidson MG, Breitschwerdt ED, Walker DH, et al. Vascular permeability and coagulation during Rickettsia rickettsii infection in dogs. Am J Vet Res 1990; 51:165–170. 10. Harrell GT, Aikawa JF. Pathogenesis of circulatory failure in Rocky Mountain spotted fever: alterations in the blood volume and the thiocyanate space at various stages of the disease. Arch Intern Med 1949; 83:331–347.
The relative importance of the various potential, pathological conditions including hypoxemia, ischemia, cerebral edema, and inflammation in cerebral pathophysiology has not been determined. Because of the importance of rickettsial meningoencephalitis in the outcome of infection, the neuropathogenesis and neuropathophysiology of rickettsial diseases merits careful investigation. Hepatic Involvement in Rickettsial Diseases Hepatic infection and lesions occur in the life-threatening rickettsioses, but the hepatic rickettsial burden and pathology are minor.
Stimulation of spleen cells collected from R. typhi-infected mice with concanavalin A during this period yields lower production of IL-2 and IL-12 than those of naïve mice (34). Similarly, serum IL-10 concentrations are increased in the sera of patients with Mediterranean spotted fever, and rickettsial antigen-stimulated peripheral blood mononuclear cells from patients with this rickettsiosis also produce increased amounts of IL-10 (35). Prospects for Vaccines Against Rickettsial Diseases After recovery from a spotted fever or typhus rickettsiosis, patients and experimental animals develop solid immunity that prevents reinfection.