By Wayne Burleson, Sandro Carrara
This ebook offers a scientific method of studying the tough engineering difficulties posed through the necessity for safety and privateness in implantable clinical units (IMD). It describes intimately new matters termed as light-weight safety, as a result linked constraints on metrics resembling to be had strength, power, computing skill, region, execution time, and reminiscence necessities. assurance comprises vulnerabilities and safety throughout a number of degrees, with simple abstractions of cryptographic companies and primitives corresponding to public key cryptography, block ciphers and electronic signatures. specialists from laptop safety and Cryptography current new study which indicates vulnerabilities in current IMDs and proposes suggestions. specialists from privateness expertise and coverage will talk about the societal, criminal and moral demanding situations surrounding IMD defense in addition to technological recommendations that construct at the most recent in desktop technological know-how privateness learn, in addition to light-weight ideas acceptable for implementation in IMDs.
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Additional resources for Security and Privacy for Implantable Medical Devices
Valgimigli et al. OXIDATION + + O2 GOD β -D-glucose H2O2 Hydrogen peroxide D-glucono-1,5-lactone HYDROLYSIS Gluconic acid Fig. 12 GOD-mediated oxidation of glucose Fig. 13 (a) Overall topology of GOD holoenzyme; (b) molecular structure of FAD cofactor; (c) subunit structure of GOD showing FAD (red spacefill) • The enzyme is glycosylated, having a carbohydrate content of approximately 16–20% (w/w). • The total dimensions of the dimer are 70 × 55 × 80 Ångstroms [1 Å = 10−10 m]. 2. 5). 2 mM for molecular oxygen  (which can be seen as the second substrate).
Irrespectively of its inorganic or organic nature, the mediator must generate a reversible redox couple. e. e. oxidising compounds) and, of course, electrodes. Such reversible redox couples are also often referred to as fast mediators. The biological samples in which glucose must be measured often also contain a number of endogenous or exogenous chemicals that are themselves electroactive. In many cases, however, oxidation of these compounds requires the application of relatively high potentials.
5 100 100 3 20 500 30 3,000 20 Urea Bilirubin Fig. 22 Chemical structure of various interferents Sugars that share strong similarities with the molecular structure of glucose can be erroneously recognised by the enzyme, thus leading to a non-specific enzymatic activity. In a glucosensor this directly translates into an overestimation of the glycaemic readings. g. by lipids, haematocrit) Oxidation/reduction of compounds with intrinsic electrochemical activity FAD N NH Tyr 73 N N O NH O O His 563 N OH Phe 418 OH HO N H O OH HO Trp 430 OH NH HN O HN Hydrogen bonds N O NH2 NH HN Arg 516 H2N NH Asn 518 O Non-ligand residues involved in hydrophobic contacts O Atoms involved in hydrophobic contacts Fig.