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By John W. Fenton II (auth.), Barry W. Festoff M.D., Daniel Hantaï M.D., Ph.D. (eds.)

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14. 15. 16. E. Reich, Activation of plasminogen: a general mechanism for producing localized extracellular proteolysis, in: "Molecular Basis of biological degradative processes". D. , Eds. New York: Academic Press, p 155 (1978). ' K Dan\il, PA. Andreasen, J. Gr\ilndahl-Hansen, P. S. Nielsen, and L. Skriver, Plasminogen activators, tissue degradation and cancer. Adv. in Cancer Res. 44: 139 (1985). F. D. VassalIi, and K Dan\il, Urokinase type plasminogen activator: proenzyme, receptor and inhibitors.

52: 127 (1984). M. Nilsson, H. Ljungner, and L. Tengborn, Two different mechanisms in patients with venous thrombosis and defective fibrinolysis: low concentration of plasminogen activator or increased concentration of plasminogen activator inhibitor. Br. Med. J. 290: 1453 (1985). 20 A KEY MOLECULE DICTATING AND REGULATING SURFACE PLASMIN FORMATION: THE RECEPTOR FOR UROKINASE PLASMINOGEN ACTIVATOR FRANCESCO BLASI, M. VITIORIA CUBELLIS, ANN LOURING ROLDAN, MARIA TERESA MASUCCI, NIELS BEHRENDT\ VINCENT ELLIS\ ETIORE APPELLA2 AND KELD DAN01 Institute of Microbiology University of Copenhagen Oster Farimagsgade 2A 1353 Copenhagen K, Denmark; IFinsen Laboratory, Rigshospitalet Strandboulevarden 49 2100 Copenhagen 0, Denmark; and 2Laboratory of Cell Biology NCI, National Institutes of Health Bethesda, MD 20892, USA INTRODUCTION Regulation of cell to cell contacts and of cell migration is thought to require the action of protease systems which are needed to sever the ties that link cells to other cells and to the extracellular matrix, and to overcome barriers like the basement membranes.

J. Cell Bioi. 103: 1415 (1987). 20. L. Ossowski, and E. Reich, Antibodies to plasminogen activator inhibit human tumor metastasis. Cell 35: 611 (1983). 21. VJ. W. Law, A. Corti, E. Appella, and F. BIas~ Modulation of metastatic potential by cell surface urokinase of murine cells. Cancer Res. 48: 1270 (1988). 22. K Tryggvason, M. Hoyhtya, and T. Salo, Proteolytic degradation of extracellular matrix in tumor invasion. Biochim. Biophys. Acta 907: 191 (1987). 23. D. Collen, On the regulation and ('ontrol of fibrinolysis.

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